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US 12,188,008 B2Granted
Recombinant host cells and methods for the production of glyceric acid and downstream products
AssigneeLygos, Inc.
InventorsJeffrey A. Dietrich, Mario Ouellet, Johan van Walsem
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Abstract
Methods and materials related to producing glyceric acid and downstream products are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, methods and materials for producing glycolic acid by direct fermentation from sugars are disclosed.
Claims14
A recombinant host cell, comprising:
- a glyceric acid biosynthetic pathway, comprising heterologous nucleic acids encoding a 3-phosphoglycerate phosphatase and a 2-phosphoglycerate phosphatase, wherein the expression of the heterologous nucleic acids produces glyceric acid, wherein:
- the 3-phosphoglycerate phosphatase has the amino acid sequence selected from SEQ ID NO:
- 9 and SEQ ID NO:
- 7, and the 2-phosphoglycerate phosphatase has the amino acid sequence of SEQ ID NO:
- 1;
- and the recombinant host cell is a yeast cell or a prokaryotic cell.
3 more elements
Dependencies are inferred from the claim text.