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US 12,187,795 B2Granted
Anti-LAG-3 antibodies and methods of use thereof
AssigneeAgenus Inc.
InventorsNicholas Stuart Wilson, David Adam Savitsky, Shawn Michael Jennings, Marc van Dijk, Cornelia Anne Mundt
Life of this patent
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Abstract
The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
Claims18
An isolated polynucleotide encoding an antibody comprising complementarity determining regions CDRH1, CDRH2, CDRH3, CDRL1, CDRL2 and CDRL3,
- wherein CDRH1, CDRH2, and CDRH3 are found in a heavy chain variable region (VH) comprising the amino acid sequence of SEQ ID NO:
- 65;
- and CDRL1, CDRL2 and CDRL3 are found in a light chain variable region (VL) comprising the amino acid sequence of SEQ ID NO:
- 73.
1 more element
Dependencies are inferred from the claim text.