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US 12,187,784 B2Granted
Processes for making a cellular fibronectin composition
AssigneeCombangio, Inc.
InventorsSpencer Alford, Audrey Smith
Life of this patent
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Abstract
The present application provides methods and processes for making and using a fibronectin composition, as well as methods for treating ocular conditions and/or disorders with the cellular fibronectin composition described herein.
Claims20
A method of making a composition comprising mesenchymal stem cell (MSC)-derived fibronectin (FN), comprising:
- (a) culturing mesenchymal stem cells (MSCs) in a cell culture medium, thereby generating conditioned medium that comprises factors comprising MSC-derived FN secreted by the MSCs;
- (b) harvesting the conditioned medium thereby producing harvested conditioned medium;
- and
- (c) filtering harvested conditioned medium to produce processed conditioned medium;
- wherein the MSCs are bone marrow-derived.
2 more elements
Dependencies are inferred from the claim text.