Compounds for treatment of cancer
AssigneeUniversity of Tennessee Research Foundation
InventorsWei Li, Duane D Miller, Kinsie E. Arnst, Dong-Jin Hwang
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
Claims16
A compound of Formula IX having the structure
- wherein R4 and R5 are independently hydrogen, O-alkyl, O-haloalkyl, F, Cl, Br, I, haloalkyl, CN, —CH2CN, NH2, hydroxyl, —(CH2)iNHCH3, —(CH2)iNH2, —(CH2)iN(CH3)2, —OC(O)CF3, C1-C5 linear or branched alkyl, alkylamino, aminoalkyl, —OCH2Ph, —NHCO-alkyl, COOH, —C(O)Ph, C(O)O-alkyl, C(O)H, —C(O)NH2 or NO2;
- A′ is halogen;
- substituted or unsubstituted single-, fused- or multiple-ring, aryl or (hetero)cyclic ring systems;
- substituted or unsubstituted, saturated or unsaturated N-heterocycles;
- substituted or unsubstituted, saturated or unsaturated S-heterocycles;
- substituted or unsubstituted, saturated or unsaturated O-heterocycles;
- substituted or unsubstituted, saturated or unsaturated cyclic hydrocarbons;
- or substituted or unsubstituted, saturated or unsaturated mixed heterocycles;
- wherein said A′ ring is optionally substituted by 1-5 substituents which are independently O-alkyl, O-haloalkyl, F, Cl, Br, I, haloalkyl, CN, —CH2CN, NH2, hydroxyl, —(CH2)iNHCH3, —(CH2)iNH2, —(CH2)iN(CH3)2, —OC(O)CF3, C1-C5 linear or branched alkyl, alkylamino, aminoalkyl, —OCH2Ph, —NHCO-alkyl, COOH, —C(O)Ph, C(O)O-alkyl, C(O)H, —C(O)NH2 or NO2;
- i is an integer between 1-5;
- and
- n is an integer between 1-3;
- or its pharmaceutically acceptable salt, hydrate, polymorph, or isomer.
A compound, wherein the compound is at least one of 1-chloro-7-(4-fluorophenyl)isoquinoline, 7-(4-fluorophenyl)-1-(1H-indol-5-yl)isoquinoline, 7-(4-fluorophenyl)-1-(3,4,5-trimethoxyphenyl)isoquinoline, 1,7-bis(4-fluorophenyl)isoquinoline, 1,7-bis(3,4,5-trimethoxyphenyl)isoquinoline, 1-(4-fluorophenyl)-7-(3,4,5-trimethoxyphenyl)isoquinoline, 1-(1H-indol-5-yl)-7-(3,4,5-trimethoxyphenyl)isoquinoline, or 1-chloro-7-(3,4,5-trimethoxyphenyl)isoquinoline.
Dependencies are inferred from the claim text.