High purity 2-naphthylacetonitrile and method for producing same
AssigneeApi Corporation
InventorsMasaki Nagahama, Daiki Okado, Hirotsugu Taniike
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Abstract
High purity 2-naphthylacetonitrile with fewer impurities that is useful as a starting material or intermediate for the synthesis of various pharmaceutical products, agricultural chemicals, and chemical products, and a production method thereof. A high purity 2-naphthylacetonitrile having an HPLC purity of 2-naphthylacetonitrile of not less than 95 area %, and containing naphthalene compounds represented by the formulas (a)-(j) at a content of a predetermined area % or below. A method for producing high purity 2-naphthylacetonitrile.
Claims8
A method for producing a high purity 2-naphthylacetonitrile, the method comprising reacting 2-naphthylacetic acid and a halogenating agent, mixing a first reaction starting material comprising an obtained acid halide compound of formula (5), in which X is a halogen atom,
- and a second reaction starting material comprising sulfamide at a temperature of from 10° C. to 100° C., and
- raising the temperature to from 85° C. to 120° C. to give 2-naphthylacetonitrile.
A method for producing high purity 2-naphthylacetonitrile, the method comprising:
- subjecting 2′-acetonaphthone to a Willgerodt reaction, optionally in the presence of an additive, to obtain an amide compound;
- hydrolyzing the amide compound;
- and
- liberating 2-naphthylacetic acid to give 2-naphthylacetic acid;
- mixing a first reaction starting material comprising the liberated 2-naphthylacetic acid, a halogenating agent, and a first organic solvent, and a second reaction starting material comprising sulfamide and a second organic solvent at a temperature in a range of from 10° C. to 100° C.;
- and
- raising the temperature to a range of from 85° C. to 120° C. to give 2-naphthylacetonitrile.
Dependencies are inferred from the claim text.