Thyromimetics with a biphenylmethane scaffold and their use
AssigneeInternational Society for Drug Development S.R.L.
InventorsGuido Puricelli, Simona Rapposelli, Grazia Chiellini, Amedeo Columbano, Andrea Perra, Massimiliano Runfola, Sheraz Gul
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Abstract
The invention concerns a compound of Formula (I) or a salt thereof, wherein R1 is H, (C1-C3)alkyl or CF3; R2 is H, (C1-C3)alkyl or CF3; A is CH2COOH, XCH2COOCH2CH3, XCH2COOH, XCH2CH2NH2, where X is nitrogen or oxygen atom; Ar is an aromatic fragment selected from the group consisting of (Ar1), (Ar2) and (Ar3); where R3 is H, —CH3, —CH2CH3 or CH3CO—, R4 is H or —CH3, R5 is H or —CH3, and R6 is H or —CH3. The compounds of Formula (I) can be used in the treatment of diseases modulated by thyroid hormone receptor-beta (TRb or TRβ).
Claims16
A compound of Formula (I) or a salt thereof:
- Wherein
- R1 is H, (C1-C3)alkyl or CF3;
- R2 is H, (C1-C3)alkyl or CF3;
- A is CH2COOH, XCH2COOCH2CH3, XCH2COOH, XCH2CH2NH2, where X is nitrogen or oxygen atom;
- Ar is an aromatic fragment selected from the group consisting of
- where
- R3 is H, —CH3, —CH2CH3 or CH3CO—,
- R4 is H or —CH3,
- R5 is H or —CH3, and
- R6 is H or —CH3.
Dependencies are inferred from the claim text.