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US 12,187,662 B2Granted
FOXM1 inhibitor compositions and methods of using the same
AssigneeThe Board of Trustees of the University of Illinois
InventorsJohn A. Katzenellenbogen, Benita Katzenellenbogen, Sung Hoon Kim, Noah Bindman
Life of this patent
Estimating the term…
Abstract
Provided are compounds, or pharmaceutically acceptable salts thereof, which are useful for inhibiting FOXM1, inhibiting cancer growth, and/or treating cancer. In particular, these compounds and their corresponding quaternary ammonium salts may be used to treat various forms of breast cancer.
Claims37
A compound of formula (I), or a pharmaceutically acceptable salt thereof,
- wherein
- G is an optionally substituted polycycloalkylidene;
- RA and RB at each occurrence are independently halogen, C1-4alkyl, or C1-4haloalkyl;
- R1 and R2 are independently —OH, halogen, —CN, —OC2-8alkylene-L-T, or —OR3, and at least one of R1 and R2 is —OR3;
- L is a linker;
- T is a fluorescence acceptor or a fluorescence donor;
- R3 is —C4-8alkylene-NRxRy, —CH2CH2O—CH2CH2—NRxRy, or —(CH2CH2O)2—CH2CH2—NRxRy;
- Rx and Ry at each occurrence are independently C1-4alkyl or —C2-4alkylene-OH, or
- Rx and Ry together with the nitrogen to which they are attached form a 4- to 8-membered heterocycle or heteroaryl, wherein the heterocycle and heteroaryl are optionally substituted with 1, 2, 3, or 4 substituents independently selected from the group consisting of C1-4alkyl, halogen, —OH, C1-4haloalkyl, and —C1-4alkylene-OH;
- m is 0, 1, 2, 3, or 4;
- and
- n is 0, 1, 2, 3, or 4.
9 more elements
A pharmaceutically acceptable salt of a compound of Formula (I),
- Wherein
- G is an optionally substituted polycycloalkylidene;
- RA and RB at each occurrence are independently halogen, C1-4alkyl, or C1-4haloalkyl;
- R1 and R2 are independently —OH, halogen, —CN, —OC2-8alkylene-L-T, or —OR3, and at least one of R1 and R2 is —OR3;
- L is a linker;
- T is a fluorescence acceptor or a fluorescence donor;
- R3 is —(CH2CH2O)p—C2-8alkylene-[NRxRyRz]+·X−;
- Rx and Ry at each occurrence are independently C1-4alkyl or —C2-4alkylene-OH, or
- Rx and Ry together with the nitrogen to which they are attached form a 4- to 8-membered heterocycle or heteroaryl, wherein the heterocycle and heteroaryl are optionally substituted with 1, 2, 3, or 4 substituents independently selected from the group consisting of C1-4alkyl, halogen, —OH, C1-4haloalkyl, and —C1-4alkylene-OH;
- Rz is C1-4alkyl or C2-4alkylene-OH;
- m is 0, 1, 2, 3, or 4;
- n is 0, 1, 2, 3, or 4;
- p is 0, 1, 2, 3, 4, or 5;
- and
- X− is a counterion.
12 more elements
Dependencies are inferred from the claim text.