Processing system for multiple tangential flow filtration stations in bioprocessing applications

A method for performing multiple tangential flow filtration (TFF) processes, the method comprising:

• supporting a plurality of tangential flow filtration (TFF) systems on a single support frame, each of the tangential flow filtration systems comprising a product vessel, a tangential flow filtration (TFF) filter and a pump for circulating a flow of liquid between said product vessel and said filter;
• and
• controlling said plurality of tangential flow filtration systems with a single electrical controller, wherein the method is used as part of diafiltration process during which liquid or buffer is added to the product vessel to maintain a relatively constant volume as filtrate removal occurs, using a buffer container, containing a liquid to be added to the product vessel in order to change a solvent environment of the product during a diafiltration process, whereby either a single buffer container is connected to multiple TFF systems, or each system comprises its own buffer container;
• wherein each TFF system has level sensors for detecting a liquid level in its respective product vessel and an air-in-tube detector and the method includes maintaining diafiltration points using the level sensors and detecting air in a tube downstream of a Y-connector connecting tubes from the product and the buffer containers to said tube feeding the product vessel when that feed to the product vessel is exhausted using the air-in-tube detector to determine diafiltration endpoints.