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US 12,186,413 B2Granted
Non-cellular root canal filler and non-cellular dental tissue regeneration promotion kit
AssigneeKowa Company, Ltd.
InventorsMisako Nakashima, Koichiro Iohara
Life of this patent
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Abstract
A non-cellular root canal filler comprises a tetrahydroisoquinoline compound or a pharmaceutically acceptable salt thereof, or a solvate of the compound or the salt, and a dental tissue regeneration promotion kit comprises a pretreatment agent comprising a serine protease, and the non-cellular root canal filler.
Claims12
A non-cellular root canal filler comprising a tetrahydroisoquinoline compound, wherein the tetrahydroisoquinoline compound is selected from the group consisting of:
- (+)-4-[[2-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2 (1H-yl]ethylamino]methyl]-N-isopropylaniline monofumarate;
- and
- (+)-N-[3-(methanesulfonylamino)benzyl]-2-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2 (1H)-yl]ethanamine monocitrate.
A dental tissue regeneration promotion kit comprising:
- a pretreatment agent comprising a serine protease;
- and
- a non-cellular root canal filler comprising a tetrahydroisoquinoline compound, wherein the tetrahydroisoquinoline compound is selected from the group consisting of:
- (+)-4-[[2-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2 (1H)-yl]ethylamino]methyl]-N-isopropylaniline monofumarate;
- and
- (+)-N-[3-(methanesulfonylamino)benzyl]-2-[6-fluoro-3-(4-fluorobenzyl)-3,4-dihydroisoquinolin-2 (1H)-yl]ethanamine monocitrate.
3 more elements
Dependencies are inferred from the claim text.