Bi-dota complex-loaded dendritic polymer nanoparticles
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorsJesus Manuel Perez, Santimukul Santra
Life of this patent
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Abstract
Disclosed are compositions comprising polymeric nanoparticles and methods of using the same. The polymeric nanoparticles can be conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein. The polymeric nanoparticles can also comprises an imaging compound and/or a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle. A cancer therapeutic composition comprising the nanoparticle is also disclosed. The disclosed nanoparticles can be used to target and deliver imaging and/or therapeutic compounds to cancer cells, thereby identifying and/or treating a solid tumor cell target. Methods for treating cancer, such as lung cancer, using the polymeric nanoparticles are also disclosed.
Claims14
A method of identifying a solid tumor cell target, comprising,
- 1) contacting a cell with an effective amount of a composition comprising at least one polymeric nanoparticle conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein, wherein the nanoparticle further comprises an imaging compound and an anti-cancer agent;
- wherein the polymeric nanoparticle comprises a hyperbranched polyester and/or polyamide polymer, wherein the hyperbranched polyester and/or polyamide polymer has the formula:
- wherein A is a heteroatom independently selected from nitrogen and oxygen;
- R1 and R2 are independently selected from hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, and substituted or unsubstituted alkynyl;
- 1 is an integer from 1 to 5;
- m is 0, 1, or 2;
- n is an integer from 1 to 5;
- and o is an integer from 2 or greater;
- 2) identifying one or more nanoparticles bound to the cells by using imaging devices;
- and optionally,
- 3) monitoring the solid tumor cell target by repeating 1) and 2).
Dependencies are inferred from the claim text.