Compositions and methods for treatment of pre-cancerous skin lesions
AssigneeWashington University
InventorsLynn Cornelius, Shadmehr Demehri, Raphael Kopan
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Abstract
The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
Claims19
A topical composition comprising about 2% to about 5% (wt/wt) 5-fluorouracil (5-FU) and about 0.002% to about 0.005% (wt/wt) calcipotriol.
A method of treating a noncancerous skin lesion in a subject in need thereof, the method comprising, topically administering to the noncancerous skin lesion a composition comprising a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
A method of treating non-melanoma skin cancer in a subject in need thereof, the method comprising, topically administering to the non-melanoma skin cancer a composition comprising a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
Dependencies are inferred from the claim text.