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US 12,186,368 B2Granted
Compositions and methods for treatment of protease mediated disease
AssigneeThe Regents of the University of California
InventorsMichael E. Selsted, Dat Q. Tran
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Abstract
A method is provided for a condition related to the activity of a protease through the administration of a θ-defensin, analog, or derivative is described. Suitable proteases include metalloproteases and cysteine proteases such as Cathepsin-C. The θ-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally.
Claims15
A method of inhibiting a metalloprotease and a cysteine protease in a subject in need thereof, comprising:
- injectably administering to the subject in need thereof a θ-defensin in an amount effective to inhibit the metalloprotease and the cysteine protease;
- wherein the θ-defensin is administered intravenously, subcutaneously, or intraperitoneally;
- and wherein the administration reduces TNF-alpha mediated inflammation in the subject.
A method of inhibiting a metalloprotease or a cysteine protease in a subject in need thereof, comprising:
- administering to the subject in need thereof a θ-defensin in an amount effective to inhibit the metalloprotease or the cysteine protease, wherein the θ-defensin is a mini-θ-defensin.
Dependencies are inferred from the claim text.