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US 12,186,350 B2Granted
Antitumor effect potentiator
AssigneesNational Cerebral and Cardiovascular Center, Kabushiki Kaisha Yakult Honsha
InventorsKenji Kangawa, Takashi Nojiri, Motofumi Kumazoe, Yasutake Tanaka, Yoshiyuki Shishido, Takashi Asahara, Takahito Miura, Keisuke Taniguchi
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Abstract
An activator suitable for immune response in tumor immunotherapy using an immune checkpoint inhibitor. An agent suitable for potentiating an antitumor effect of an immune checkpoint inhibitor, may contain a probiotic and a prebiotic as active ingredients.
Claims2
A method for potentiating an antitumor effect of an immune checkpoint inhibitor, the method comprising:
- administering an effective amount of a probiotic, a prebiotic, and an immune checkpoint inhibitor to a subject in need thereof,
- wherein the probiotic comprises Lactobacillus casei YIT9029 (FERM BP-1366) and Bifidobacterium breve YIT12272 (FERM BP-11320),
- the prebiotic is a galactooligosaccharide, and
- the immune checkpoint inhibitor is an anti-PD-1 antibody.
1 more element
Dependencies are inferred from the claim text.