Nitroxyl donors with improved therapeutic index
AssigneeCardioxyl Pharmaceuticals, Inc.
InventorsVincent Jacob Kalish, Frederick Arthur Brookfield, Stephen Martin Courtney, Lisa Marie Frost, John P. Toscano
Life of this patent
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Abstract
The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.
Claims20
A method of treating ischemia/reperfusion injury, comprising administering an effective amount of a compound of formula (3), or a pharmaceutical composition comprising the compound of formula (3), to a patient in need thereof, wherein the compound of formula (3) is represented by formula:
- wherein R is hydrogen, —(C1-C6)alkyl, —(C2-C4)alkenyl, phenyl, benzyl, cyclopentyl, cyclohexyl, —(C5-C7)heterocycloalkyl, benzyloxy, —O—(C1-C6)alkyl, —NH2, —NH—(C1-C4)alkyl, or —N((C1-C4)alkyl)2, wherein said —(C1-C6)alkyl, —(C2-C4)alkenyl, phenyl, benzyl, cyclopentyl, cyclohexyl, —(C5-C7)heterocycloalkyl, benzyloxy, —O—(C1-C6)alkyl, —NH—(C1-C4)alkyl, or —N((C1-C4)alkyl)2 can be unsubstituted or substituted with one or more substituents selected from halo, —(C1-C6)alkyl, —(C2-C4)alkenyl, —(C2-C3)alkynyl, -(5- or 6-membered)heteroaryl, —O—(C1-C6)alkyl, —S—(C1-C6)alkyl, —C(halo)3, —CH(halo)2, —CH2(halo), —CN, —NO2, —NH2, —NH—(C1-C4)alkyl, —N(—(C1-C4)alkyl)2, —C(═O)(C1-C4)alkyl, —C(═O)O(C1-C4)alkyl, —OC(═O)(C1-C4)alkyl, —OC(═O)NH2, —S(═O)(C1-C4)alkyl, or —S(═O)2(C1-C4)alkyl.
Dependencies are inferred from the claim text.