Bismuth-thiol compositions and methods of use
AssigneeMicrobion Corporation
InventorsBrett Hugh James Baker, Jeffrey W. Millard
Life of this patent
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Abstract
The invention relates to Bis-thiol compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating, managing or lessening the severity of pulmonary infections in a subject, the method comprising administering to the subject a bismuth-thiol (BT) composition that comprises at least one BT compound.
Claims18
An aerosol comprising a plurality of dispersed liquid droplets in a gas, said liquid droplets comprising a bismuth-thiol (BT) composition comprising bismuth-1,2-ethanedithiol (BisEDT) suspended therein, wherein the BT composition comprises a plurality of BisEDT particles having a D90 of less than about 2 μm as measured by laser diffraction;
- and
- wherein at least 70% of the total number of dispersed liquid droplets have a mass median aerodynamic diameter (MMAD) from about 0.4 μm to about 5 μm as measured by cascade impaction or laser time of flight.
A pharmaceutical composition comprising a bismuth-thiol (BT) composition that comprises BisEDT suspended therein, wherein the BT composition comprises a plurality of BisEDT particles having a D90 of less than or equal to 1.9 μm as measured by laser diffraction.
Dependencies are inferred from the claim text.