Sustained release cowpea mosaic virus or virus-like particle therapeutic constructs for the treatment of cancer
AssigneeCase Western Reserve University
InventorsNicole F. Steinmetz, Frank Alexander Veliz, Brylee David B. Tiu
Life of this patent
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Abstract
A nanoparticle construct includes a plurality of plant virus or virus-like particles electrostatically coupled to a plurality of nanoparticles having a different surface charge than the plant virus or virus-like particles. The nanoparticle construct upon delivery to a subject can provide a sustained release of the plant virus or virus-like particles and/or nanoparticles to a cell or tissue of the subject.
Claims10
A nanoparticle construct for in situ delivery of plant virus or plant virus-like particles to a cell or tissue of interest of a subject, the nanoparticle construct comprising:
- a plurality of plant virus or plant virus-like particles, wherein the plant virus or plant virus-like particle is a rod-shaped virus particle, a plant picornavirus, or a filamentous plant virus or plant virus-like particle;
- and
- a plurality of dendrimers electrostatically coupled to the plant virus or plant virus-like particles, the nanoparticle construct upon in situ delivery to a subject providing a sustained release of the plant virus or plant virus-like particles and/or dendrimers to the cell or tissue.
Dependencies are inferred from the claim text.