# US 12,181,551 B2 · Magnetic resonance fingerprinting imaging method with variable number of echoes > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,181,551 B2 - Document ID: US12181551B2 - Status: Granted - Kind: B2 - Application number: 18/014,151 - Filed: 2022-11-18 - Published: 2024-03-28 - Granted: 2024-12-31 - Earliest claimed: 2021-11-26 - Assignees: Zhejiang University - Applicants: Zhejiang University - Inventors: Huihui Ye; Jinmin Xu; Huafeng Liu - Web page: https://patentgrep.com/patent/US12181551B2 ## CPC - G01R 33/543: {Control of the operation of the MR system, e.g. setting of acquisition parameters prior to or during MR data acquisition, dynamic shimming, use of one or more scout images for scan plane prescription (G01R33/546 takes precedence)} - G01R 33/243: {Spatial mapping of the polarizing magnetic field} - G01R 33/246: {Spatial mapping of the RF magnetic field B1} - G01R 33/4818: {MR characterised by data acquisition along a specific k-space trajectory or by the temporal order of k-space coverage, e.g. centric or segmented coverage of k-space} - G01R 33/4828: {Resolving the MR signals of different chemical species, e.g. water-fat imaging} - G01R 33/50: based on the determination of relaxation times {, e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences} - G01R 33/5608: {Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels (image data processing or generation, in general G06T)} - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) ## Abstract The present invention discloses a magnetic resonance fingerprinting imaging method with variable number of echoes, in addition to conventional MRF coding such as changing the excitation pulse angle, the method also introduces the change of the number of echoes, so that quantitative maps of B0, B1+, T1 and T2* can be obtained in a single scan. Further, if the echo time corresponding to the in-phase, opposed-phase and in-phase of water and fat is set for three consecutive echoes, the present invention can also image water and fat, and achieve the accurate quantification of B0, B1+, T1w, T1F, [T2*]w and [T2*]F. Through in vivo experiments and simulations, the effectiveness of the present invention has been proved. Therefore, the present invention can provide multiple information representations for common brain diseases (glioma) and fatty diseases (such as lipoma, fatty liver, etc.), which is conducive to clinical diagnosis and treatment. ## Claims ### Claim 1 A computer-implemented magnetic resonance fingerprinting imaging method with variable number of echoes, wherein, comprising the following steps: (1) designing and generating a magnetic resonance fingerprinting imaging sequence based on variable number of echoes according to a required quantitative tissue parameters and system parameters, the tissue parameters comprise longitudinal relaxation time T1 and transverse relaxation time T2*, the system parameters comprise main magnetic field inhomogeneity B0 and RF magnetic field (radio frequency magnetic field) B1+; (2) importing the magnetic resonance fingerprinting imaging sequence into a magnetic resonance scanner, scanning a subject to obtain the original k-space data; (3) reconstructing the original k-space data to obtain a series of images; (4) giving a required quantitative dynamic variation range and discretization step of tissue parameters and system parameters, a dictionary reflecting the temporal variation of echo signal is established based on Bloch equation; (5) matching the temporal variation signal of each pixel of the reconstructed images in step (3) with the echo signal in the dictionary one by one, so as to obtain the specific tissue parameter values for each pixel, and then obtain the quantitative image of the above tissue parameters and system parameters; (6) saving the quantitative image of the above tissue parameters and system parameters in a database for viewing. ### Claim 2 (depends on 1) The computer-implemented magnetic resonance fingerprinting imaging method according to claim 1, wherein, the magnetic resonance fingerprinting imaging sequence designed in the step (1) is based on a spoiled gradient recalled echo sequence prepared by an inversion pulse, mainly comprising an inversion pulse excitation module and a gradient recalled echo signal acquisition module with variable number of echoes; in the gradient recalled echo signal acquisition module with variable number of echoes, the duration of each TR is not exactly the same, and the number of echoes contained in each TR is not exactly the same, at the same time, the flip angle of the excitation pulse used by each TR and the echo time TEs in the same TR is necessary to be optimized. ### Claim 3 (depends on 1) The computer-implemented magnetic resonance fingerprinting imaging method according to claim 1, wherein, Bloch equation describes the magnetic resonance fingerprinting imaging sequence designed in the step (1), giving the tissue parameters and system parameters of the required quantitative, giving the sequence parameters as the input of Bloch equation, and outputting the echo signal time series reflecting the given parameters under the designed magnetic resonance fingerprinting imaging sequence, the sequence parameters comprise TR durations, flip angles, the number of echoes used in each TR and TEs of each echo. ### Claim 4 (depends on 2) The computer-implemented magnetic resonance fingerprinting imaging method according to claim 2, wherein, some TRs of the gradient recalled echo signal acquisition module with variable number of echoes use four echoes, and the corresponding TR is a long TR, other TRs use one echo, and the corresponding TR is a short TR, the adjacent short TR module and long TR module form a dual TR module. ### Claim 5 (depends on 4) The computer-implemented magnetic resonance fingerprinting imaging method according to claim 4, wherein, the duration of the short TR is 12 ms, the duration of the long TR is 48 ms. ### Claim 6 (depends on 4) The computer-implemented magnetic resonance fingerprinting imaging method according to claim 4, wherein, when the method is applied to the water-fat separation imaging, the first three echoes in the long TR modules have the water-fat in-phase, water-fat opposed-phase and water-fat in-phase echo times respectively. ### Claim 7 (depends on 6) The computer-implemented magnetic resonance fingerprinting imaging method according to claim 6, wherein, the TEs of the four echoes in the long TR are 2.4 ms, 13.2 ms, 24 ms and 31 ms, the TEs of the echo in the short TR is 2.4 ms. ### Claim 8 (depends on 1) The computer-implemented magnetic resonance fingerprinting imaging method according to claim 1, wherein, when the method is applied to the water-fat separation imaging, after a series of images are reconstructed in step (3), the Dixon method is used to decompose the images into water signal map, fat signal map and main magnetic field B0 inhomogeneity map; further using the water signal map and fat signal map to calculate the fat fraction distribution map through the following formula, and incorporating the fat fraction into Bloch equation; F ⁢ F = F F + W wherein, FF is the fat fraction, F is the fat signal, and W is the water signal.