# US 12,181,483 B2 · Kit comprising antibody binding acrolein-protein conjugate for diagnosing nephropathy

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- Number: US 12,181,483 B2
- Document ID: US12181483B2
- Status: Granted
- Kind: B2
- Application number: 17/929,254
- Filed: 2022-09-01
- Published: 2024-02-01
- Granted: 2024-12-31
- Earliest claimed: 2022-04-27
- Assignees: National Yang Ming Chiao Tung University
- Applicants: National Yang Ming Chiao Tung University
- Inventors: Hsiang-Tsui Wang
- Web page: https://patentgrep.com/patent/US12181483B2

## CPC

- G01N 33/6893: {related to diseases not provided for elsewhere}
- G01N 2800/347: Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A biomarker includes acrolein-protein conjugate (Acr-PC). An assay kit includes an antibody capable of binding to the biomarker for diagnosing nephropathy, monitoring the progression of nephropathy, or assessing the therapeutic response of nephropathy. The antibody includes a heavy chain having the amino acid sequence of SEQ ID NO:1 and a light chain having the amino acid sequence of SEQ ID NO:2.

## Claims

### Claim 1

A kit for diagnosing nephropathy, monitoring the progression of nephropathy, or assessing the therapeutic response of nephropathy, comprising;
a buffer; and
an antibody comprising a heavy chain having the amino acid sequence of SEQ ID NO:1 and a light chain having the amino acid sequence of SEQ ID NO:2.