# US 12,181,410 B2 · Sensing arrangement and corresponding detector device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,181,410 B2 - Document ID: US12181410B2 - Status: Granted - Kind: B2 - Application number: 17/798,432 - Filed: 2021-02-11 - Published: 2023-03-09 - Granted: 2024-12-31 - Earliest claimed: 2020-02-12 - Assignees: Universitat De Barcelona; Technische Universität Braunschweig - Applicants: Universitat De Barcelona; Technische UniversitäT Braunschweig - Inventors: Olga Casals Guillen; Nicolai Markiewicz; Cristian Fàbrega Gallego; Andreas Hans Wilhelm Waag; Juan Daniel Prades García - Web page: https://patentgrep.com/patent/US12181410B2 ## CPC - G01N 21/6428: {Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" (in vivo A61B5/00; immunoassay G01N33/53)} - G01N 21/78: producing a change of colour - G01N 21/31: Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry {(G01N21/72 takes precedence)} - G01N 21/645: {Specially adapted constructive features of fluorimeters} - G01N 2021/7783: {Transmission, loss} - G01N 2021/7786: {Fluorescence} - G01N 2201/062: LED's - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract A sensing arrangement and corresponding detector device includes a sensing area, for accommodating a sensing substance selected for experimenting an optical response as a response of an external stimulus; a light emitter, for emitting light towards said sensing area; a light receiver, for receiving a light from said sensing area; a substrate having a first substrate surface and a second substrate surface; wherein, said light emitter includes a first LED and the light receiver includes a second LED, both LEDs formed on the first substrate surface; and the sensing arrangement further includes a trench, formed between the first LED and the second LED. ## Claims ### Claim 1 A sensing arrangement, comprising: a sensing area, configured for accommodating a sensing substance selected for experimenting an optical response as a response of an external stimulus; a light emitter, configured for emitting a first light towards the sensing area; and a light receiver, configured for receiving a second light from the sensing area; a substrate having a first substrate surface and a second substrate surface, opposite the first substrate surface; wherein, the light emitter comprises a first LED, formed on the first substrate surface; the light receiver comprises a second LED, formed on the first substrate surface; and the sensing arrangement further comprises a trench, formed between the first LED and the second LED, wherein said first LED and said second LED, are formed from one single semiconductor stack. ### Claim 2 (depends on 1) The sensing arrangement according to claim 1, further comprising a sensing substance arranged in the sensing area, wherein the sensing substance is of the kind that experiments an optical response as a response of an external stimulus. ### Claim 3 (depends on 2) The sensing arrangement according to claim 2, wherein the optical response is at least one of: a color change; a transparency change; a change in absorbance in at least one electromagnetic spectral band; a fluorescent response; or combinations thereof. ### Claim 4 (depends on 2) The sensing arrangement according to claim 2, wherein the external stimulus is at least one of: a presence of a chemical substance, a physical change, in particular of temperature, electro-magnetic field, electro-magnetic radiation; a presence of a biological entity, in particular cells, microorganisms or other biological material; or combinations thereof. ### Claim 5 (depends on 1) The sensing arrangement according to claim 1, wherein the substrate is transparent, and the sensing area is provided on the second substrate surface. ### Claim 6 (depends on 5) The sensing arrangement according to claim 5, wherein the trench contains a light blocking layer, configured to block a direct light from the first LED to the second LED. ### Claim 7 (depends on 5) The sensing arrangement according to claim 5, further comprising a microfluidic channel arranged in the sensing area and configured to contain the sensing substance. ### Claim 8 (depends on 1) The sensing arrangement according to claim 1, wherein the sensing area is provided in the trench. ### Claim 9 (depends on 8) The sensing arrangement according to claim 8, further comprising a microfluidic channel arranged in the sensing area and configured to contain the sensing substance. ### Claim 10 (depends on 9) The sensing arrangement according to claim 9, wherein the microfluidic channel is formed by a cap arranged covering the trench. ### Claim 11 (depends on 8) The sensing arrangement according to claim 8, wherein the substrate is reflective viewing from the first substrate surface. ### Claim 12 (depends on 8) The sensing arrangement according to claim 8, wherein the substrate is transparent, and the sensing arrangement further comprises a reflective coating provided covering at least part of the substrate, wherein reflection is produced towards the substrate. ### Claim 13 (depends on 1) The sensing arrangement according to claim 1, further comprising a reflective coating arranged covering at least the part of the external surface of the first LED that is not facing the sensing area, wherein reflection is produced towards the first LED. ### Claim 14 (depends on 1) The sensing arrangement according to claim 1, wherein the sensing area is provided with a textured surface, preferably in the form of ridges. ### Claim 15 (depends on 14) The sensing arrangement of claim 14, wherein the textured surface is in the form of ridges. ### Claim 16 (depends on 1) The sensing arrangement according to claim 1, wherein the light receiver further comprises at least one further LED, formed on the first substrate surface and configured for receiving a further light from the sensing area. ### Claim 17 (depends on 1) The sensing arrangement according to claim 1, wherein said first LED and said second LED are dual emitters and receivers, so that the second LED is further configured for emitting light towards said sensing area and said first LED is further configured for receiving light from said sensing area. ### Claim 18 (depends on 1) A detector device comprising a sensing arrangement as defined in claim 1. ### Claim 19 (depends on 18) The detector device of claim 18, further comprising at least one additional sensing arrangement, wherein the substrate of the sensing arrangement and the substrate of each of said at least one additional sensing arrangement is a common substrate.