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US 12,181,388 B2Granted
Device for tissue section immobilization and retention
AssigneeSingular Genomics Systems, Inc.
InventorsYuji Ishitsuka, Zhenmin Hong, Eli N. Glezer, Hu Cang, William Dempsey, Weiqiao Ding, Jaekyung Koh, Mohammad Vatankhah Varnosfaderani
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Abstract
Disclosed herein, inter alia, are devices and methods for transfer and analyses of tissue sections using carrier substrates.
Claims24
A device comprising:
- a solid support comprising a plurality of discrete tissue samples attached to the solid support, wherein each discrete tissue sample comprises
- a tissue section comprising a width of about 1 mm to about 10 mm and a thickness of about 1 μm to about 50 μm;
- and
- a hydrogel substrate attached to the tissue section,
- wherein the hydrogel substrate of each tissue section does not contact other tissue sections.
2 more elements
A device comprising:
- a solid support comprising a plurality of discrete tissue portions attached to the solid support at a first adhesion strength, wherein each tissue portion comprises a tissue section comprising a thickness of about 1 μm to about 50 μm and a polymer substrate bound to the tissue section at a second adhesion strength, wherein the first adhesion strength is greater than the second adhesion strength and wherein each polymer substrate does not contact other tissue sections.
Dependencies are inferred from the claim text.