# US 12,180,617 B2 · Thermally and dimensionally stabilized electrospun compositions and methods of making same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,180,617 B2 - Document ID: US12180617B2 - Status: Granted - Kind: B2 - Application number: 17/976,140 - Filed: 2022-10-28 - Published: 2023-08-10 - Granted: 2024-12-31 - Earliest claimed: 2014-01-30 - Assignees: Poly-Med, Inc. - Applicants: Poly-Med, Inc. - Inventors: Michael Scott Taylor; Seth Dylan McCullen - Web page: https://patentgrep.com/patent/US12180617B2 ## CPC - D01F 6/84: from copolyesters - D01D 1/02: Preparation of spinning solutions - D01D 5/003: {the material being a polymer solution or dispersion (D01D5/0053 takes precedence)} - D01F 6/625: {derived from hydroxy-carboxylic acids, e.g. lactones} - D04H 1/435: Polyesters - D04H 1/728: by electro-spinning {(electro-spinning methods and apparatus D01D5/0007)} - D10B 2331/041: derived from hydroxy-carboxylic acids, e.g. lactones - D10B 2331/06: polyethers - D10B 2509/00: Medical; Hygiene - Y10T 428/249921: Web or sheet containing structurally defined element or component - D01F: CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS - D01D: MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS - D04H: MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL (weaving D03; knitting D04B; braiding D04C; net-making D04G; sewing D05B; tufting D05C; finishing non-woven fabrics D06); FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING {; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION}(non-woven fabrics having an intermediate or external layer of a different kind, e.g. of woven fabric, B32B) - D10B: INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES - Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION ## Abstract Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed with thermally unstable fibers to yield a stabilizing effect without altering morphological properties of a fiber system. Via this, one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state. ## Claims ### Claim 1 A dimensionally stable nonwoven material comprising: two independent fiber populations; a first population of fibers, the first population of fibers being thermally unstable fibers consisting of a poly (glycolic-co-lactic) acid (PLGA) copolymers having a monomer ratio of glycolide of from 80 to 95 and lactide of from 20 to 5; and a second population of fibers, the second population of fibers being thermally stable fibers consisting of poly (paradioxanone) polymer (PPD); wherein the thermally unstable fibers are present in the dimensionally stable nonwoven material in an amount of 49% or more; wherein the thermally stable fibers are present in the dimensionally stable nonwoven material in an amount of from 13 to 49% by weight; wherein the thermally unstable fibers are dimensionally unstable at a temperature of about 50° C.; wherein the thermally stable fibers are dimensionally stable at a temperature of about 50° C.; wherein the first population of fibers and the second population of fibers are comingled and distributed throughout the dimensionally stable nonwoven material; wherein each fiber population is not a composite fiber wherein an individual fiber comprises nonstable and stabilizing elements; and wherein said material does not decrease in size more than 10% at temperatures of 30° C. to 50° C. ### Claim 2 (depends on 1) The dimensionally stable nonwoven material of claim 1, wherein the poly (paradioxanone) polymer (PPD) comprises at least 30 weight percent of the dimensionally stable nonwoven material. ### Claim 3 (depends on 1) The dimensionally stable nonwoven material of claim 1, wherein porosity is 75% or greater. ### Claim 4 (depends on 1) The dimensionally stable nonwoven material of claim 1, wherein porosity of the dimensionally stable nonwoven material increases as the first population of fibers is absorbed. ### Claim 5 (depends on 1) The dimensionally stable nonwoven material of claim 1, further comprising one or more bioactive or therapeutic agents. ### Claim 6 (depends on 1) The dimensionally stable nonwoven material of claim 1, wherein the dimensionally stable nonwoven material is made by a process comprising spun melt, spun bond, melt blowing, solution spinning, wet spinning, centrifugal melt spinning, liquid shear spinning, or electrospinning. ### Claim 7 (depends on 1) The dimensionally stable nonwoven material of claim 1, wherein the thermally unstable fibers are present in an amount of from 49 to 85% by weight and the thermally stable fibers are present in an amount of from 15 to 49% by weight. ### Claim 8 (depends on 1) The dimensionally stable nonwoven material of claim 1, wherein the thermally unstable fibers are present in an amount of from 80 to 85% by weight and the thermally stable fibers are present in an amount of from 15 to 20% by weight. ### Claim 9 (depends on 1) The dimensionally stable nonwoven material of claim 1, wherein the thermally unstable fibers are present in an amount of from 60 to 80% by weight and the thermally stable fibers are present in an amount of from 20 to 40% by weight. ### Claim 10 (depends on 1) The dimensionally stable nonwoven material of claim 1, wherein the thermally unstable fibers are present in an amount of from 65 to 70% by weight and the thermally stable fibers are present in an amount of from 30 to 35% by weight. ### Claim 11 (depends on 1) The dimensionally stable nonwoven material of claim 1, wherein the thermally unstable fibers are present in an amount of from 49 to 60% by weight and the thermally stable fibers are present in an amount of from 40 to 51% by weight. ### Claim 12 A method of forming a dimensionally stable nonwoven material, comprising: a) dissolving thermally unstable poly (glycolic-co-lactic) acid (PLGA) copolymers having a monomer ratio of glycolide of from 80 to 95 and lactide of from 20 to 5 in a solvent, thereby forming a first solution; b) dissolving thermally stable poly (paradioxanone) polymer (PPD) in a solvent, thereby forming a second solution; and c) dispensing the first and second solutions onto a substrate to form a dimensionally stable nonwoven material comprising a first population of fibers and a second population of fibers, the first population of fibers being thermally unstable fibers formed from the first solution and the second population of fibers being thermally stable fibers formed from the second solution; wherein the thermally unstable fibers are present in the dimensionally stable nonwoven material in an amount of 49% by weight or more; wherein the thermally stable fibers are present in the dimensionally stable nonwoven material in an amount of from 13 to 49% by weight; wherein the thermally unstable fibers are dimensionally unstable at a temperature of about 50° C.; wherein the thermally stable fibers are dimensionally stable at a temperature of about 50° C.; and wherein the first population of fibers and the second population of fibers are comingled and distributed throughout the dimensionally stable nonwoven material.