# US 12,180,459 B2 · Kazachstania turicensis CAU Y1706 and composition using same

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- Number: US 12,180,459 B2
- Document ID: US12180459B2
- Status: Granted
- Kind: B2
- Application number: 17/425,079
- Filed: 2020-01-23
- Published: 2022-04-07
- Granted: 2024-12-31
- Earliest claimed: 2019-01-23
- Assignees: Chung Ang University Industry Academic Cooperation Foundation
- Applicants: Chung Ang University Industry Academic Cooperation Foundation
- Inventors: Won Yong Kim; Jong Hwa Kim; Ki Young Kim; Kanjanasuntree Rungravee
- Web page: https://patentgrep.com/patent/US12180459B2

## CPC

- C12N 1/16: Yeasts; Culture media therefor
- A23L 31/15: Extracts
- A61K 8/9728: Fungi, e.g. yeasts
- A61K 36/06: Fungi, e.g. yeasts
- A61P 17/00: Drugs for dermatological disorders
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61Q 19/00: Preparations for care of the skin
- C12N 1/165: Yeast isolates
- A23L 33/14: Yeasts or derivatives thereof
- C12R 2001/645: Fungi {; Processes using fungi}
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS

## Abstract

The present invention relates to a novel Kazachstania turicensis CAU Y1706 and a composition using same, and more specifically, to a Kazachstania turicensis CAU Y1706 (Accession No.: KCTC13794BP) strain, and a pharmaceutical composition, a food composition, a cosmetic composition, and a probiotic composition for preventing or treating inflammatory diseases, comprising the strain or a culture thereof as an active ingredient.

## Claims

### Claim 1

A method for treating an inflammatory disease comprising administering to a subject in need thereof an effective amount of a composition comprising Kazachstania turicensis CAU Y1706 (accession number: KCTC13794BP) strain or a culture thereof as an active ingredient.

### Claim 2 (depends on 1)

The method of claim 1, wherein the Kazachstania turicensis CAU Y1706 (accession number: KCTC13794BP) has anti-inflammatory activity.

### Claim 3 (depends on 1)

The method of claim 1, wherein the Kazachstania turicensis CAU Y1706 (accession number: KCTC13794BP) has acid resistance or bile resistance.

### Claim 4 (depends on 1)

The method of claim 1, wherein the Kazachstania turicensis CAU Y1706 (accession number: KCTC13794BP) improves Th1/Th2 immune response imbalance.

### Claim 5 (depends on 1)

The method of claim 1, wherein the inflammatory disease is any one selected from the group consisting of acute or chronic organ transplant rejection, graft-versus-host disease, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory skin disease, multiple sclerosis, pancreatitis, trauma-induced shock, bronchial asthma, allergic rhinitis, allergic conjunctivitis, cystic fibrosis, acute bronchitis, chronic bronchitis, acute bronchiolitis, chronic bronchiolitis, osteoarthritis, gout, spondyloarthropathy, ankylosing spondylitis, Reiter's syndrome, psoriatic arthropathy, enteric spondylitis, juvenile arthritis, juvenile ankylosing spondylitis, reactive arthropathy, infectious arthritis, post-infectious arthritis, Lou Gehrig's disease, polyarteritis nodosa, hypersensitivity vasculitis, granulomatosis Lou Gehrig's disease, polymyalgia rheumatica, articular cell arteritis, calcium crystallization arthropathy, pseudo gout, non-articular rheumatism, bursitis, tendinitis, epicondylitis, neuropathic joint diseases (neuropathic joint disease or charcot joint), hemarthrosis, allergic purpura, hypertrophic osteoarthropathy, multicentral reticulocytoma, scoliosis, hemochromatosis, hemoglobinopathy, hyperproteinemia, hypogammaglobulinemia, familial Mediterranean fever, Behcet's disease, systemic lupus erythematosus, recurrent fever, sepsis, septic shock, acute respiratory distress syndrome, multiple organ failure, chronic obstructive pulmonary disease, rheumatoid arthritis, acute lung injury, broncho-pulmonary dysplasia, type 1 diabetes, type 2 diabetes, arteriosclerosis, Alzheimer's dementia, familial cold autoinflammatory syndrome, Muckle-Wells syndrome, neonatal multisystem inflammatory disease, chronic infantile neurologic cutaneous articular syndrome, adult-onset Still's disease, contact dermatitis, hydatidiform mole, Pyogenic Arthritis, Pyoderma gangrenosum and Acne (PAPA) syndrome, hyperimmunoglobulin d syndrome, cryopyrin-associated periodic syndrome, keratitis, conjunctivitis, retinitis, retinal vasculitis, uveitis, blepharitis, dry eye, progressive systemic sclerosis, polymyositis, autoimmune encephalomyelitis, myasthenia gravis, polyarteritis nodosa and fibromyalgia syndrome.

### Claim 6 (depends on 5)

The method of claim 5, wherein the inflammatory skin disease is any one selected from the group consisting of psoriasis, atopic dermatitis, dermatitis eczema, contact dermatitis, seborrheic dermatitis, pneumoconiosis rosacea, lichen planus, vasculitis, pityriasis pilaris, cellulitis, folliculitis, pemphigus, bullous pemphigus, epidermal blistering, urticaria, angioedema, erythema and cutaneous eosinophilia.

### Claim 7

A method for improving an inflammatory disease comprising administering to a subject in need thereof an effective amount of a composition comprising Kazachstania turicensis CAU Y1706 (accession number: KCTC13794BP) strain or a culture thereof as an active ingredient.

### Claim 8

A method for improving an inflammatory disease comprising applying to a subject in need thereof an effective amount of a cosmetic composition comprising Kazachstania turicensis CAU Y1706 (accession number: KCTC13794BP) strain or a culture thereof as an active ingredient.

### Claim 9 (depends on 7)

The method of claim 7, wherein the composition is a food composition, probiotic composition, or an enteral composition.

### Claim 10

A method of immunomodulation comprising administering to a subject in need thereof an effective amount of a composition comprising Kazachstania turicensis CAU Y1706 (accession number: KCTC13794BP) strain or a culture thereof as an active ingredient.