# US 12,180,252 B2 · Peptide derived from PEP27 peptide and uses thereof

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- Number: US 12,180,252 B2
- Document ID: US12180252B2
- Status: Granted
- Kind: B2
- Application number: 18/210,179
- Filed: 2023-06-15
- Published: 2023-09-28
- Granted: 2024-12-31
- Earliest claimed: 2021-02-01
- Assignees: Industry-Academic Cooperation Foundation, Chosun University
- Applicants: Industry Academic Cooperation Foundation Chosun University
- Inventors: Yoon Kyung Park; Hee Kyoung Kang
- Web page: https://patentgrep.com/patent/US12180252B2

## CPC

- C07K 14/3156: {from Streptococcus pneumoniae (Pneumococcus) (Streptokinase C07K14/3153)}
- A23K 20/147: Polymeric derivatives, e.g. peptides or proteins
- A23K 20/195: Antibiotics
- A23L 33/18: Peptides; Protein hydrolysates
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61P 31/04: Antibacterial agents
- A61Q 17/005: {Antimicrobial preparations}
- A61Q 19/007: {Preparations for dry skin}
- A61Q 19/10: Washing or bathing preparations
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- C12R 2001/46: Streptococcus {; Enterococcus; Lactococcus}
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A23K: FODDER
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

In a method of killing or reducing a growth of methicillin-resistant Staphylococcus aureus (S. aureus), a composition including a peptide consisting of the amino acid sequence of SEQ ID NO:2 or 3 is administered to a subject in need thereof. The peptide can be usefully applied as an active ingredient for antibiotics, cosmetic compositions, food additives, feed additives, biological pesticides and quasi-drugs.

## Claims

### Claim 1

A method of killing or reducing a growth of methicillin-resistant Staphylococcus aureus (S. aureus), the method comprising:
administering a composition comprising a peptide consisting of the amino acid sequence of SEQ ID NO:2 or 3 to a subject in need thereof.

### Claim 2 (depends on 1)

The method of claim 1, wherein the methicillin-resistant Staphylococcus aureus (S. aureus) is S. aureus MW2.

### Claim 3 (depends on 1)

The method of claim 1, wherein the composition further comprises at least one antibiotic selected from the group consisting of meropenem, ceftazidim and ceftriaxone.

### Claim 4

A method for treating an abscess comprising:
administering a composition comprising a peptide consisting of the amino acid sequence of SEQ ID NO:2 or 3 to a subject in need thereof,
wherein the abscess is formed after infection with Staphylococcus aureus MW2.