# US 12,180,244 B2 · (Thio)nicotinamide ribofuranoside salts and compositions, methods of making, and uses thereof

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- Number: US 12,180,244 B2
- Document ID: US12180244B2
- Status: Granted
- Kind: B2
- Application number: 17/820,816
- Filed: 2022-08-18
- Published: 2023-04-06
- Granted: 2024-12-31
- Earliest claimed: 2018-05-18
- Assignees: Biosynth AG
- Applicants: Biosynth AG
- Inventors: Urs Spitz; Günter Schabert; Aysel Soydemir; Lukas Wick
- Web page: https://patentgrep.com/patent/US12180244B2

## CPC

- C07H 1/00: Processes for the preparation of sugar derivatives
- C07H 1/06: Separation; Purification
- A23L 33/15: Vitamins
- A61K 31/7064: containing condensed or non-condensed pyrimidines
- C07H 19/048: Pyridine radicals
- C07B 2200/13: Crystalline forms, e.g. polymorphs
- C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07B: GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C67/47; telomerisation C08F)

## Abstract

The present invention relates to crystalline (thio)nicotinamide ribofuranoside salts, methods of making such crystalline salts, a pharmaceutical composition comprising same, and use of said crystalline salts as nutritional (dietary) supplements. Furthermore, the present invention relates to a composition comprising amorphous (thio)nicotinamide ribofuranoside salts and its use as nutritional (dietary) supplement.

## Claims

### Claim 1

A crystalline nicotinamide-2,3,5-tri-O-acetyl-β-D-ribofuranoside bromide of formula O-Va:
wherein R is acetyl, characterized by a powder X-ray diffraction pattern substantially as defined in FIG. 1; or
a crystalline nicotinamide-β-D-ribofuranoside bromide of formula O-Ia:
characterized by a powder X-ray diffraction pattern substantially as defined in FIG. 2; or
a crystalline nicotinamide-β-D-ribofuranoside chloride of formula O-Ib:
characterized by a powder X-ray diffraction pattern as defined in FIG. 4; or
a crystalline thionicotinamide-2,3,5-tri-O-acetyl-β-D-ribofuranoside bromide of formula S-Va:
wherein R is acetyl, characterized by a powder X-ray diffraction pattern substantially as defined in FIG. 5; or
a crystalline thionicotinamide-β-D-ribofuranoside bromide of formula S-Ia:
characterized by a powder X-ray diffraction pattern substantially as defined in FIG. 6; or
a crystalline thionicotinamide-β-D-ribofuranoside chloride of formula S-Ib:
characterized by a powder X-ray diffraction pattern substantially as defined in FIG. 7; or
a crystalline thionicotinamide-2,3,5-tri-O-acetyl-β-D-ribofuranoside chloride of formula S-Vb:
wherein R is acetyl, characterized by a powder X-ray diffraction pattern substantially as defined in FIG. 8.

### Claim 2 (depends on 1)

A composition comprising the crystalline salt of claim 1, wherein
the composition is a nutritional supplement or a pharmaceutical composition.