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US 12,180,239 B2Granted
Organosilanes for the treatment of infections
AssigneeTopikos Scientific, Inc.
InventorsGary Allred, Lanny Liebeskind, William R. Cast, Carl Hilliard
Life of this patent
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Abstract
Organosilicon quaternary ammonium compounds, their formulations, including lyophilized solid formulations, and methods of use to treat infections in humans and animals.
Claims20
A quaternary ammonium compound of Formula:
- wherein the quaternary amine has a balancing pharmaceutically acceptable anion;
- wherein
- m is 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17;
- n is 0, 1, or 2;
- Q is —CR4R4—;
- R1 and R2 are independently at each occurrence selected from the group consisting of hydrogen and ethyl;
- R4 is independently at each occurrence selected from the group consisting of hydrogen, C1-3alkyl, C2-4alkenyl, C2-4alkynyl, halogen, and haloC1-3alkyl;
- R6 is independently at each occurrence selected from the group consisting of hydrogen, hydroxy, and C1-C6alkoxy;
- B is independently at each occurrence selected from the group consisting of
- and
- and
- M is hydrogen, sodium, potassium, cesium, or lithium.
9 more elements
Dependencies are inferred from the claim text.