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US 12,180,219 B2Granted
Process for preparing beta 3 agonists and intermediates
AssigneeMerck Sharp & Dohme Corp.
InventorsFeng Xu, Zhuqing Liu, Richard Desmond, Jeonghan Park, Alexei Kalinin, Birgit Kosjek, Hallena Strotman, Hongmei Li, Johannah Moncecchi
Life of this patent
Estimating the term…
Abstract
The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.
Claims8
A crystalline form of Compound I-7:
- characterized by a powder X-ray diffraction (XRPD) pattern comprising °2θ peaks at about 5.5, 8.7, and 11.0.
Dependencies are inferred from the claim text.