# US 12,180,217 B2 · Compounds and methods for treatment of viral infections

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- Number: US 12,180,217 B2
- Document ID: US12180217B2
- Status: Granted
- Kind: B2
- Application number: 18/601,528
- Filed: 2024-03-11
- Published: 2024-07-25
- Granted: 2024-12-31
- Earliest claimed: 2022-03-02
- Assignees: Gilead Sciences, Inc.
- Applicants: Gilead Sciences, Inc.
- Inventors: Mark J. Bartlett; Daniel H. Byun; Yifan Deng; Jennifer L. Cosman Ellis; Rao V. Kalla; Richard L Mackman; Dustin S. Siegel; Xianhuang Zeng
- Web page: https://patentgrep.com/patent/US12180217B2

## CPC

- C07D 487/04: Ortho-condensed systems
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 31/14: for RNA viruses
- C07B 59/005: {Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids}
- C07D 519/00: Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07F 9/6561: containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07B: GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C67/47; telomerisation C08F)
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)

## Abstract

Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

## Claims

### Claim 1

A compound of Formula:
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The compound of claim 1, wherein the compound is

### Claim 3

A compound of Formula:
or a pharmaceutically acceptable salt thereof.

### Claim 4 (depends on 3)

The compound of claim 3, wherein the compound is

### Claim 5

A compound of Formula:
or a pharmaceutically acceptable salt thereof.

### Claim 6 (depends on 5)

The compound of claim 5, wherein the compound is

### Claim 7 (depends on 1)

A pharmaceutical composition comprising the compound of claim 1, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

### Claim 8 (depends on 2)

A pharmaceutical composition comprising the compound of claim 2, and one or more pharmaceutically acceptable excipients.

### Claim 9 (depends on 3)

A pharmaceutical composition comprising the compound of claim 3, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

### Claim 10 (depends on 4)

A pharmaceutical composition comprising the compound of claim 4, and one or more pharmaceutically acceptable excipients.

### Claim 11 (depends on 5)

A pharmaceutical composition comprising the compound of claim 5, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

### Claim 12 (depends on 6)

A pharmaceutical composition comprising the compound of claim 6, and one or more pharmaceutically acceptable excipients.