Nicotine salts, co-crystals, and salt co-crystal complexes
AssigneeR.J. Reynolds Tobacco Company
InventorsGary M. Dull, Susana del Rio Gancedo, Judit Galcera Julia
Life of this patent
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Abstract
The invention provides certain nicotine salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, certain nicotine salt-co-crystals are described, including nicotine and two different coformers. The invention further provides methods of preparation and characterization of nicotine salts, co-crystals, and salt co-crystals. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and/or salt co-crystals are also provided.
Claims21
An oral product comprising one or more salt co-crystals selected from the group consisting of:
- a salt-co-crystal of nicotine, L-malic acid, and succinic acid;
- a salt-co-crystal of nicotine, orotic acid, and succinic acid;
- and
- a salt-co-crystal of nicotine, fumaric acid, and nicotinamide.
A pharmaceutical product comprising one or more salt co-crystals selected from the group consisting of:
- a salt-co-crystal of nicotine, L-malic acid, and succinic acid;
- a salt-co-crystal of nicotine, orotic acid, and succinic acid;
- and
- a salt-co-crystal of nicotine, fumaric acid, and nicotinamide.
A lozenge comprising one or more salt co-crystals selected from the group consisting of:
- a salt-co-crystal of nicotine, L-malic acid, and succinic acid;
- a salt-co-crystal of nicotine, orotic acid, and succinic acid;
- and
- a salt-co-crystal of nicotine, fumaric acid, and nicotinamide;
- and
- at least about 50% by weight isomalt.
Dependencies are inferred from the claim text.