Water-soluble ynamide coupling reagent and preparation method and use thereof
AssigneeXi'an Easy Peptide Biotechnology Co., Ltd.
InventorsJunfeng Zhao, Tao Liu
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Abstract
The present disclosure discloses a water-soluble ynamide coupling reagent and a method for using the water-soluble ynamide coupling reagent in the synthesis of amide, polypeptide, ester and thioester compound. The ynamide coupling reagent has the structure represented by the following formula (I): and in the formula (I), R is one selected from the group consisting of methylsulfonyl, benzenesulfonyl, p-toluenesulfonyl, trifluoroacetyl and other electron withdrawing groups.
Claims9
A water-soluble ynamide coupling reagent, wherein the ynamide coupling reagent has the structure represented by the following formula (I):
- and
- in the formula (I), R is selected from the group consisting of methylsulfonyl, benzenesulfonyl, p-toluenesulfonyl, trifluoroacetyl and other electron withdrawing groups.
Dependencies are inferred from the claim text.