# US 12,180,167 B1 · 6-[4,4-bis(4-bromophenyl)-2,5-dioxoimidazolidin-1-yl]hexanoic acid as an antimicrobial compound

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- Number: US 12,180,167 B1
- Document ID: US12180167B1
- Status: Granted
- Kind: B1
- Application number: 18/402,538
- Filed: 2024-01-02
- Granted: 2024-12-31
- Earliest claimed: 2024-01-02
- Assignees: King Faisal University
- Applicants: King Faisal University
- Inventors: Mohamed Gouda; Hany Mohamed Abd El-Lateef Ahmed; Mai Mostafa Khalaf Ali; Mohamed A. Al-Omair; Antar Amed Abdelhamid Ahmed
- Web page: https://patentgrep.com/patent/US12180167B1

## CPC

- C07D 233/76: with substituted hydrocarbon radicals attached to the third ring carbon atom
- A61K 31/4172: Imidazole-alkanecarboxylic acids, e.g. histidine
- A61P 31/04: Antibacterial agents
- A61P 31/10: Antimycotics
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

A 6-[4.4-bis(4-bromophenyl)-2,5-dioxoimidazolidin-1-yl]hexanoic acid compound, its synthesis, and its use as an antimicrobial agent.

## Claims

### Claim 1

A method of treating a microbial infection in a patient comprising administering to a patient in need thereof a therapeutically effective amount of a 6-[4,4-bis(4-bromophenyl)-2,5-dioxoimidazolidin-1-yl]hexanoic acid compound having the formula I:
wherein the microbial infection is caused by one or more bacteria or fungi selected from the group consisting of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and a combination thereof.

### Claim 2 (depends on 1)

The method of treating the microbial infection of claim 1, wherein the infection is caused by Staphylococcus aureus.

### Claim 3 (depends on 1)

The method of treating the microbial infection of claim 1, wherein the infection is caused by one or more gram negative bacteria selected from the group consisting of Pseudomonas aeruginosa, Escherichia coli, and a combination thereof.

### Claim 4 (depends on 1)

The method of treating the microbial infection of claim 1, wherein the infection is caused by Candida albicans.