# US 12,180,164 B2 · Heterocyclic compounds for the treatment of neurological and psychological disorders

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- Number: US 12,180,164 B2
- Document ID: US12180164B2
- Status: Granted
- Kind: B2
- Application number: 18/051,216
- Filed: 2022-10-31
- Published: 2023-05-18
- Granted: 2024-12-31
- Earliest claimed: 2009-06-25
- Assignees: Alkermes Pharma Ireland Limited
- Applicants: Alkermes Pharma Ireland Limited
- Inventors: Julius F. Remenar; Laura Cook Blumberg; Tarek A. Zeidan
- Web page: https://patentgrep.com/patent/US12180164B2

## CPC

- C07D 215/227: only one oxygen atom which is attached in position 2
- A61K 31/496: Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A61K 31/497: containing further heterocyclic rings
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/16: Anti-Parkinson drugs
- A61P 25/18: Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A61P 25/20: Hypnotics; Sedatives
- A61P 25/22: Anxiolytics
- A61P 25/24: Antidepressants
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 215/22: attached in position 2 or 4
- C07D 263/58: with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 401/14: containing three or more hetero rings
- C07D 413/10: linked by a carbon chain containing aromatic rings
- C07D 413/14: containing three or more hetero rings
- C07D 417/12: linked by a chain containing hetero atoms as chain links
- C07D 417/14: containing three or more hetero rings
- C07D 471/04: Ortho-condensed systems
- C07F 9/6558: containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F 9/65583: {each of the hetero rings containing nitrogen as ring hetero atom}
- C07D 241/04: having no double bonds between ring members or between ring members and non-ring members
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)

## Abstract

Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.

## Claims

### Claim 1

A compound of Formula V:
or a pharmaceutically acceptable salt thereof:
wherein
represents a single or double bond;
R5 is —CH(R10)−OR20 or —CH(R10)−OC(O)R20;
w is 4;
R10 is hydrogen; and
R20 is hydrogen.

### Claim 2 (depends on 1)

The compound of claim 1, wherein
represents a single bond.

### Claim 3 (depends on 1)

The compound of claim 1, wherein R5 is —CH(R10)—OR20.

### Claim 4 (depends on 1)

The compound of claim 1, wherein R5 is —CH(R10)—OC(O)R20.

### Claim 5 (depends on 1)

The compound of claim 1 that is