# US 12,180,162 B1 · 2-amino-4-(4-bromophenyl)-6-methoxypyridine-3,5-dicarbonitrile as an antibacterial compound

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- Number: US 12,180,162 B1
- Document ID: US12180162B1
- Status: Granted
- Kind: B1
- Application number: 18/612,563
- Filed: 2024-03-21
- Granted: 2024-12-31
- Earliest claimed: 2023-12-06
- Assignees: King Faisal University
- Applicants: King Faisal University
- Inventors: Hany Mohamed Abd El-Lateef Ahmed; Mai Mostafa Khalaf Ali; Antar Ahmed Abdelhamid Ahmed; Amer A. Amer
- Web page: https://patentgrep.com/patent/US12180162B1

## CPC

- C07D 213/73: Unsubstituted amino or imino radicals
- A61K 31/44: Non condensed pyridines; Hydrogenated derivatives thereof
- A61K 31/4412: having oxo groups directly attached to the heterocyclic ring
- A61K 31/4418: having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
- A61P 31/04: Antibacterial agents
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

An 2-amino-4-(4-bromophenyl)-6-methoxypyridine-3.5-dicarbonitrile compound, its synthesis, and its use as an antibacterial agent.

## Claims

### Claim 1

A method of treating a bacterial infection in a patient comprising administering to a patient in need thereof a therapeutically effective amount of a 2-amino-4-(4-bromophenyl)-6-methoxypyridine-3,5-dicarbonitrile compound; wherein the bacterial infection is caused by one or more gram positive bacteria selected from the group consisting of Bacillus cereus, Staphylococcus aureus, and a combination thereof; one or more gram negative bacteria selected from the group consisting of Pseudomonas aeruginosa, Escherichia coli, and a combination thereof; or a combination thereof.

### Claim 2 (depends on 1)

The method of treating the bacterial infection of claim 1, wherein the bacterial infection is caused by Bacillus cereus.

### Claim 3 (depends on 1)

The method of treating the bacterial infection of claim 1, wherein the bacterial infection is caused by Staphylococcus aureus.

### Claim 4 (depends on 1)

The method of treating the bacterial infection of claim 1, wherein the bacterial infection is caused by Pseudomonas aeruginosa.

### Claim 5 (depends on 1)

The method of treating the bacterial infection of claim 1, wherein the bacterial infection is caused by Escherichia coli.