# US 12,180,160 B1 · 1-(naphthalen-2-yloxy)-3-(piperidin-1-yl)propan-2-ol as an eco-friendly insecticidal agent against Spodoptera littoralis (boisd.)

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- Number: US 12,180,160 B1
- Document ID: US12180160B1
- Status: Granted
- Kind: B1
- Application number: 18/634,865
- Filed: 2024-04-12
- Granted: 2024-12-31
- Earliest claimed: 2023-08-28
- Assignees: King Faisal University
- Applicants: King Faisal University
- Inventors: Hany Mohamed Abd El-Lateef Ahmed; Mai Mostafa Khalaf Ali; Antar Ahmed Abdelhamid Ahmed; Mohamed A. Gad
- Web page: https://patentgrep.com/patent/US12180160B1

## CPC

- C07D 211/14: with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- A01N 43/40: six-membered rings
- A01P 7/04: Insecticides
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01P: BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS

## Abstract

A compound 1-(naphthalen-2-yloxy)-3-(piperidin-1-yl)propan-2-ol, its synthesis, and its use as an insecticidal agent.

## Claims

### Claim 1

A method of making a 1-(naphthalen-2-yloxy)-3-(piperidin-1-yl)propan-2-ol compound, the method comprising:
treating 2-((2naphthyloxy)methyl)oxirane with piperidine in a presence of triethylamine as a catalyst to obtain a crude product;
purifying the crude product by recrystallization using absolute ethyl alcohol; and
obtaining the 1-(naphthalen-2-yloxy)-3-(piperidin-1-yl)propan-2-ol compound.

### Claim 2 (depends on 1)

The method of making the 1-(naphthalen-2-yloxy)-3-(piperidin-1-yl)propan-2-ol compound of claim 1, wherein the 1-(naphthalen-2-yloxy)-3-(piperidin-1-yl)propan-2-ol compound is obtained as a yellow powder.

### Claim 3 (depends on 1)

The method of making the 1-(naphthalen-2-yloxy)-3-(piperidin-1-yl)propan-2-ol compound of claim 1, wherein the 1-(naphthalen-2-yloxy)-3-(piperidin-1-yl)propan-2-ol compound is obtained in an about 89% yield.