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US 12,180,152 B2Granted
Stilbene derivative and method for preparing same
AssigneeOzchela Inc.
InventorsMin-Kyung Lee, Jin-Kak Lee, Won-Seok Han
Life of this patent
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Abstract
This invention relates to a stilbene derivative and a method of preparing the same, and more particularly to a novel stilbene derivative for inhibiting the function of cyclophilin, which is effective at the prevention of cyclophilin-related diseases or at the treatment of symptoms of such diseases, and to a method of preparing the same.
Claims15
A compound represented by Chemical Formula 1 below or a pharmaceutically acceptable salt thereof:
- wherein A is CRa, or N, Ra is hydrogen, or a C1-C5 alkyl group,
- B is CH, or N,
- G is CRe, or N, Re is hydrogen, NH2, OH, or a C1-C10 alkyl group,
- J is CRf, or N, Rf is hydrogen, NH2, OH, or a C1-C4 alkyl group,
- M is CRg, or N, Rg is hydrogen, NH2, OH, a C1-C10 alkyl group, or COORz (Rz is a C1-C10 alkyl group),
- L is CRh or N,
- D is CRh,
- E is CRh,
- Rh is hydrogen, NH2, OH, or a C1-C5 alkyl group,
- Rx is H,
- Rc is CH2C(CH3)3,
- Rd is COOH or COOR5 (R5 is a C1-C10 alkyl group or a C3-C10 cycloalkyl group, wherein the C1-C10 alkyl group may be substituted with at least one substituent selected from the group consisting of amine, a C6-C12 aryl, a C5-C10 heterocyclic group including nitrogen as a hetero atom, and a C3-C10 cycloalkyl group), and
- wherein only one of A, B, G, J, M and L is N.
10 more elements
Dependencies are inferred from the claim text.