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US 12,180,140 B2Granted
Compounds and methods for liquid phase oligonucleotide synthesis
AssigneeHongene Biotech Corporation
InventorsGaomai Yang, Min Xie, Hongrong Yang, Shengdong Wang, Aldrich N. K. Lau, Ruiming Zou, David Yu
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Abstract
The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.
Claims26
A compound for liquid phase oligonucleotide synthesis, having the structure of Formula (IIa), (IIb), (IIc), (IId), (IIe), or (IIf):
- wherein each RA is independently C6-C30 alkyl, C6-C30 alkenyl, C6-C30 alkynyl, 6-30 membered heteroalkylene, —C(═O)(C6-C30 alkyl), or —C(═O)(6-30 membered heteroalkylene);
- y is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10;
- n is 0, 1, 2, or 3;
- and
- m is 1, 2, or 3.
2 more elements
Dependencies are inferred from the claim text.