# US 12,179,188 B2 · Ion-exchange membranes, filters, and methods

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- Number: US 12,179,188 B2
- Document ID: US12179188B2
- Status: Granted
- Kind: B2
- Application number: 18/423,071
- Filed: 2024-01-25
- Published: 2024-09-19
- Granted: 2024-12-31
- Earliest claimed: 2020-06-17
- Assignees: Entegris, Inc.
- Applicants: Entegris, Inc.
- Inventors: Maybelle Woo; Jad A. Jaber; Saksatha Ly; Jeffrey E. Townley; James Hamzik; Justin Brewster
- Web page: https://patentgrep.com/patent/US12179188B2

## CPC

- B01J 47/014: in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
- B01D 39/1692: {Other shaped material, e.g. perforated or porous sheets}
- B01D 67/00931: {by introduction of specific groups after membrane formation, e.g. by grafting}
- B01D 69/02: characterised by their properties
- B01D 71/261: {Polyethylene}
- B01D 71/262: {Polypropylene}
- B01J 47/12: characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes (electrodialysis or electro-osmosis B01D61/42)
- C08F 255/02: on to polymers of olefins having two or three carbon atoms
- C08J 5/2243: {obtained by introduction of active groups capable of ion-exchange into compounds of the type C08J5/2231}
- C08J 7/18: using wave energy or particle radiation
- B01D 2201/184: Special form, dimension of the openings, pores of the filtering elements
- B01D 2239/0414: Surface modifiers, e.g. comprising ion exchange groups
- B01D 2239/1208: Porosity
- B01D 2239/1216: Pore size
- B01D 2323/30: Cross-linking
- B01D 2323/38: Graft polymerization
- B01D 2325/16: Membrane materials having positively charged functional groups
- B01D 2325/42: Ion-exchange membranes
- C08J 2439/04: Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- C08F: MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08J: WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H (working, e.g. shaping, of plastics B29)

## Abstract

Described are ion-exchange membranes that include a porous polymeric membrane and imidazole ion-exchange groups at surfaces of the membrane; ion-exchange membranes and filters that contain the ion-exchange membranes; and methods of using the ion-exchange membranes and filters for separating charged biological molecule from a liquid.

## Claims

### Claim 1

A method of separating a charged biological molecule from a liquid using a porous ion-exchange membrane sheet, the method comprising contacting liquid that contains the charged biological molecule with a porous ion-exchange membrane comprising a porous polymeric sheet and imidazole ion-exchange groups at surfaces of the porous polymeric sheet, at an adsorption condition that causes the charged biological molecule to adsorb onto the ion-exchange membrane.

### Claim 2 (depends on 1)

The method of claim 1, wherein the charged biological molecule is plasmid DNA.

### Claim 3 (depends on 1)

The method of claim 1, wherein the adsorption condition includes a pH below 6.

### Claim 4 (depends on 1)

The method of claim 1 further comprising eluting the adsorbed biological molecule from the ion-exchange membrane at an eluting condition.

### Claim 5 (depends on 4)

The method of claim 4, wherein the eluting condition includes a pH of above 7.