# US 12,179,038 B2 · Method, a computer program and a computer system for optimization of at least one treatment plan

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- Number: US 12,179,038 B2
- Document ID: US12179038B2
- Status: Granted
- Kind: B2
- Application number: 17/415,768
- Filed: 2019-12-12
- Published: 2022-03-10
- Granted: 2024-12-31
- Earliest claimed: 2018-12-20
- Assignees: RaySearch Laboratories AB
- Applicants: RaySearch Laboratories AB
- Inventors: Albin Fredriksson; Rasmus Bokrantz; Erik Engwall; Kjell Eriksson; Lars Glimelius
- Web page: https://patentgrep.com/patent/US12179038B2

## CPC

- A61N 5/103: {Treatment planning systems}
- A61N 5/1031: {using a specific method of dose optimization}
- G16H 20/40: relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
- G16H 30/40: for processing medical images, e.g. editing
- G16H 40/20: for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
- A61N 2005/1087: {Ions; Protons}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

A method of optimizing the use of resources in treatment planning involving more than one radiation set delivered to one or more patients, the radiation sets requiring different resources, respectively, wherein the optimization is performed using an optimization problem comprising an optimization function related to the first and second sets of resources. The method may be used for optimizing one plan for one patient, or a number of plans for different patients, in such a way that the available resources are used in the best possible way.

## Claims

### Claim 1

A computer-based method of optimization of at least one treatment plan involving at least a first and a second radiation set, where the first radiation set is to be delivered to a first patient and the second radiation set is to be delivered to the first patient or to a second patient, the first and second radiation set requiring a first and a second set of resources, respectively, wherein the optimization is performed using an optimization problem comprising an optimization function related to the first and second sets of resources, wherein the optimization problem is designed to optimize the allocation of resources between at least two patients.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the optimization problem further comprises at least one optimization function arranged to restrict the use of at least one of the first and the second set of resources.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the optimization problem comprises an optimization function related to the target dose to be delivered by one of the radiation sets.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the optimization problem further comprises at least one optimization function arranged to restrict the total delivery time over all radiation sets.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the first radiation set is a photon radiation set and the second radiation set is an ion radiation set, such as a proton or carbon radiation set.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the at least one treatment plan involves delivering the first and the second radiation set as a number of fractions, and the optimization problem is designed to determine the number of fractions to be included in the plan for each of the radiation sets.

### Claim 7 (depends on 6)

The method according to claim 6, comprising the step of determining the number of fractions of the first radiation set to be included in the at least one treatment plan based on the resulting plan quality achieved with said number of fractions, using a suitable measure of quality, such as normal tissue complication probability, NTCP.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the optimization problem is designed to jointly optimize plans for multiple patients by taking into consideration resource requirements and plan quality for multiple patients in the objective function and/or constraints.

### Claim 9 (depends on 1)

The method according to claim 1, wherein the optimization problem comprises at least one optimization function arranged to favour one of the radiation sets.

### Claim 10 (depends on 1)

A computer program product comprising computer readable code means, stored on a non-transitory storage medium, which, when run in a processor will cause the processor to perform the method according to claim 1.

### Claim 11 (depends on 10)

A computer system comprising a processor, at least one data memory and a program memory, wherein the program memory comprises a computer program product according to claim 10 arranged to be run in the processor to control radiotherapy treatment planning.