# US 12,179,033 B1 · Neurostimulation treatment for abnormal connectivity with a cingulate region > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,179,033 B1 - Document ID: US12179033B1 - Status: Granted - Kind: B1 - Application number: 18/465,435 - Filed: 2023-09-12 - Granted: 2024-12-31 - Earliest claimed: 2005-03-24 - Applicants: Michael Sasha John - Inventors: Michael Sasha John - Web page: https://patentgrep.com/patent/US12179033B1 ## CPC - A61N 2/006: {for magnetic stimulation of nerve tissue} - A61B 5/0263: {using NMR} - A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging - A61N 2/00: Magnetotherapy - A61N 2/002: {in combination with another treatment} - A61N 2/004: {specially adapted for a specific therapy} - A61M 2230/10: Electroencephalographic signals - A61N 1/0529: {Electrodes for brain stimulation} - A61N 1/0534: {Electrodes for deep brain stimulation} - A61N 1/36025: {for treating a mental or cerebral condition} - A61N 1/36082: {Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease} - A61N 1/36103: {Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke} - A61N 1/37247: {User interfaces, e.g. input or presentation means} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A method to guide a targeted neurostimulation to the brain of a patient. Neuroimaging data is sensed from the brain of the patient. A processor is used to evaluate the neuroimaging data in order to calculate result data for a modeled functional measure of a particular brain network which defines a first brain region and a second brain region. A target location is determined in the first brain region based upon the result data and a functional connection measure between first and second brain region. A transcranial magnetic stimulator is adjusted to provide a magnetic stimulation signal for stimulation of the target location. ## Claims ### Claim 1 A method of guiding the provision of targeted magnetic neurostimulation of a patient suffering an unwanted symptom comprising: a. evaluating neuroimaging data that is magnetic resonance imaging data sensed from the brain of a patient; b. said evaluating neuroimaging data including operating a processor of a computer for calculating result data for at least one modeled functional connection measure value of a selected brain network model having a first brain region and at least a second brain region of said patient using said neuroimaging data; c. determining a target location of the first brain region of said patient, said target location being identified, at least in part, based upon the result data of the at least one modeled functional connection measure value, said at least one modeled functional connection measure value statistically measuring interaction of the first brain region and the at least second brain region, wherein the first brain region is a division within a left dorsolateral prefrontal cortex and the at least second brain region is a division within a cingulate region; d. adjusting at least one transcranial magnetic stimulator used to provide a magnetic stimulation signal for stimulation of the target location to treat the patient, wherein the magnetic stimulation signal is provided by at least one transcranial magnetic stimulator; and e. providing the magnetic stimulation signal by the at least one transcranial magnetic stimulator during an interval of a treatment therapy. ### Claim 2 (depends on 1) The method of claim 1 wherein the at least second brain region further comprises at least a third brain region which is an insula. ### Claim 3 (depends on 1) The method of claim 1 wherein the neuroimaging data comprises functional neuroimaging data and the target location of the first brain region is selected due to the modeled functional connection measure value with the at least second brain region being evaluated as abnormal. ### Claim 4 (depends on 3) The method of claim 3 wherein the functional neuroimaging data undergoes correlation analysis to determine correlated activity between the first brain region and the at least second brain region. ### Claim 5 (depends on 3) The method of claim 3 wherein the functional neuroimaging data is submitted to voxelwise correlation analysis. ### Claim 6 (depends on 3) The method of claim 3 wherein the functional neuroimaging data is submitted to partial least squares analysis. ### Claim 7 (depends on 3) The method of claim 3 wherein the functional neuroimaging data is submitted to path analysis. ### Claim 8 (depends on 3) The method of claim 3 wherein the functional neuroimaging data is used to generate connectivity coefficients between areas of the first and the at least second brain regions. ### Claim 9 (depends on 3) The method of claim 3 wherein the functional neuroimaging data is used to generate measurements of network interaction between areas of the first and the at least second brain regions. ### Claim 10 (depends on 1) The method of claim 1 wherein the neuroimaging data comprises functional neuroimaging data and the target location of a first brain region is identified using the modeled functional connection measure value with the at least second brain region that meets at least one treatment criterion such that a modeled connectivity value is below a specified value. ### Claim 11 (depends on 1) The method of claim 1 wherein the neuroimaging data comprises both structural data and functional data which are both used to determine a target area in the first brain region that interacts with a second target area. ### Claim 12 (depends on 1) The method of claim 1 wherein the unwanted symptom is related to a mood disorder which is depression. ### Claim 13 (depends on 1) The method of claim 1 wherein the unwanted symptom is related to a mood disorder which is bipolar disorder. ### Claim 14 (depends on 1) The method of claim 1 wherein the unwanted symptom is related to a mood disorder which includes symptoms of depression. ### Claim 15 (depends on 1) The method of claim 1 wherein the neuroimaging data comprises functional neuroimaging data and the modeled functional connection measure value is from the selected brain network model and is used to determine the target location of the first brain region that has a connectivity coefficient value with the at least second brain region that meets at least one treatment criterion compared to a reference value. ### Claim 16 (depends on 1) The method of claim 1 wherein the cingulate region is an anterior cingulate cortex. ### Claim 17 (depends on 1) The method of claim 1 wherein the cingulate region includes a subgenual cingulate region. ### Claim 18 (depends on 1) The method of claim 1 wherein the modeled functional connection measure value of the first brain region to the at least second brain region of said patient is abnormal. ### Claim 19 (depends on 1) The method of claim 1 wherein the modeled functional connection measure value is calculated as part of the selected brain network model used to determine the target location of the first brain region that has a modeled functional connection with the at least second brain region and the modeled functional connection value is below a specified value. ### Claim 20 (depends on 1) The method of claim 1 wherein the magnetic stimulation signal is provided to the target location to treat the patient by causing a change in correlation of activity of the at least second brain region with activity in the first brain region. ### Claim 21 (depends on 1) The method of claim 1 wherein the magnetic stimulation signal is provided to the target location to treat the patient by normalizing a measure value for the first brain region and the at least second brain region of the selected brain network model of the patient. ### Claim 22 A method of guiding the provision of targeted magnetic neurostimulation of a patient suffering an unwanted symptom comprising: a. using evaluated neuroimaging data that is magnetic resonance imaging data sensed from the brain of a patient for treatment of a patient during a treatment session, said using of said evaluated neuroimaging data includes obtaining from a processor a processor calculated result data for at least one modeled functional connection measure value, said at least one modeled functional connection measure value statistically measuring interaction of a selected brain network model having a first brain region and at least a second brain region of said patient based upon said neuroimaging data; b. identifying a target location of the first brain region of said patient, said target location being at least in part based upon the processor calculated result data of at least one modeled functional connection measure value of the first brain region to the at least second brain region, wherein the first brain region is a division within a left dorsolateral prefrontal cortex and the at least second brain region is a division within a cingulate region; c. providing said target location for guiding the adjustment of at least one transcranial magnetic stimulator for generating a treatment magnetic stimulation signal for stimulation of the target location to treat the patient during the treatment session; and, d. providing the magnetic stimulation signal by the at least one transcranial magnetic stimulator during an interval of said treatment session. ### Claim 23 (depends on 22) The method of claim 22 wherein the at least second brain region further comprises at least a third brain region which is an insula. ### Claim 24 (depends on 22) The method of claim 22 wherein the neuroimaging data comprises functional neuroimaging data and the target location of the first brain region is selected due to the modeled functional connection measure value with the at least second brain region that is abnormal. ### Claim 25 (depends on 24) The method of claim 24 wherein the functional neuroimaging data undergoes correlation analysis to determine correlated activity between the first brain region and the at least second brain region. ### Claim 26 (depends on 22) The method of claim 22 wherein the cingulate region is an anterior cingulate cortex. ### Claim 27 (depends on 22) The method of claim 22 wherein the cingulate region includes a subgenual cingulate region. ### Claim 28 (depends on 22) The method of claim 22 wherein the unwanted symptom is related to a mood disorder which includes symptoms of depression.