# US 12,178,950 B2 · Treatment fluid multi-stream blood warmer

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- Number: US 12,178,950 B2
- Document ID: US12178950B2
- Status: Granted
- Kind: B2
- Application number: 18/224,127
- Filed: 2023-07-20
- Published: 2023-11-09
- Granted: 2024-12-31
- Earliest claimed: 2016-12-14
- Assignees: NxStage Medical, Inc.
- Applicants: NxStage Medical, Inc.
- Inventors: Dennis M. Treu
- Web page: https://patentgrep.com/patent/US12178950B2

## CPC

- A61M 1/36: Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation {; Extra-corporeal blood circuits}
- A61M 1/1601: {Control or regulation}
- A61M 1/1664: {with temperature control}
- A61M 1/3403: {Regulation parameters}
- A61M 1/3623: {Means for actively controlling temperature of blood}
- A61M 5/44: having means for cooling or heating the devices or media
- A61M 2205/3331: Pressure; Flow
- A61M 2205/3334: Measuring or controlling the flow rate
- A61M 2205/3368: Temperature
- A61M 2205/366: by liquid heat exchangers
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. A blood treatment system treats blood with multiple fluids and performs fluid balancing on a patient's blood compartment. Multiple streams influence the patient temperature but only a subset of the fluids are dynamically temperature regulated. The system regulates a temperature of the flow, for example, of dialysate in order to regulate the return temperature of blood, in such a way that the temperature effect of the multiple streams is compensated.

## Claims

### Claim 1

A method of regulating blood return temperature in an extracorporeal blood treatment, comprising:
actively regulating a fluid temperature regulator power output, using feedback control based on a blood return temperature signal, to control a temperature of a subset of multiple medicament streams that flow into, or contact, flowing blood;
detecting a change in a flow rate or temperature of any one of the multiple medicament streams; and
resetting a rate of the fluid temperature regulator power output using feedforward control responsively to said detecting.

### Claim 2 (depends on 1)

The method of claim 1, further comprising reverting to said actively regulating using feedback control following said resetting.

### Claim 3 (depends on 1)

The method of claim 1, wherein the feedforward control includes estimating a heat transfer occurring in a blood treatment device.

### Claim 4 (depends on 1)

The method of claim 1, further comprising an initial resetting prior to said actively regulating using feedback control at a beginning of a blood treatment.

### Claim 5 (depends on 1)

The method of claim 1, wherein said detecting a change in a flow or temperature of any one of the multiple medicament streams includes detecting a change in a rate of ultrafiltration.

### Claim 6 (depends on 1)

The method of claim 1, wherein the subset is one of the multiple medicament streams.