# US 12,178,945 B2 · Catheters, catheter-based systems, and methods thereof for treating hypervolemia > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,178,945 B2 - Document ID: US12178945B2 - Status: Granted - Kind: B2 - Application number: 17/287,096 - Filed: 2019-10-24 - Published: 2021-12-16 - Granted: 2024-12-31 - Earliest claimed: 2018-10-24 - Assignees: Bard Peripheral Vascular, Inc. - Applicants: Bard Peripheral Vascular, Inc. - Inventors: Murtaza Y. Amin; Nathan Gooch; Ericka J. Prechtel; Andrew C. Sheffield; Prabir Roy-Chaudhury - Web page: https://patentgrep.com/patent/US12178945B2 ## CPC - A61M 1/1678: {intracorporal (peritoneal dialysis A61M1/28)} - A61M 27/002: {Implant devices for drainage of body fluids from one part of the body to another (intraocular A61F9/00781; middle ear A61F11/202)} - A61M 1/3403: {Regulation parameters} - A61M 1/3482: {by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter} - A61M 1/60: {Containers for suction drainage, adapted to be used with an external suction source (containers not adapted for subjection to vacuum A61M1/69)} - A61M 25/0021: {characterised by the form of the tubing (A61M25/0054 takes precedence)} - A61M 25/0067: {characterised by the distal end, e.g. tips (A61M25/0054, A61M25/04 take precedence; balloon catheters A61M25/10)} - A61M 25/0082: {Catheter tip comprising a tool} - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A catheter (100) for treating hypervolemia in a patient includes a luminal ingress (112) joined to a luminal egress (114) at a distal end portion (116) of the catheter having a closed distal end (102). The distal end portion is configured to at least temporarily reside within a vessel of the patient, the distal end portion including a semipermeable membrane. The luminal ingress is designed to convey an influent having a first osmotic concentration to the distal end portion. The semipermeable membrane is configured to pass blood-borne water from the vessel into the distal portion. The blood-borne water is absorbed by the influent to produce an effluent having a second osmotic concentration lower than the first osmotic concentration. Systems (200) with the catheter and methods for treating hypervolemia are also disclosed. ## Claims ### Claim 1 A catheter for treating hypervolemia in a patient, comprising: a distal end portion having a closed distal end configured to at least temporarily reside within a vessel of the patient; a luminal ingress joined to a luminal egress at the distal end portion, the luminal ingress designed to convey an influent having a first osmotic concentration to the distal end portion, wherein an abluminal surface of the luminal ingress is configured to be in direct contact with a fluid within the vessel of the patient; and a semipermeable membrane configured to pass blood-borne water from the vessel into at least the distal end portion, the blood-borne water absorbed by the influent to produce an effluent having a second osmotic concentration lower than the first osmotic concentration. ### Claim 2 (depends on 1) The catheter according to claim 1, wherein the catheter is a single-lumen catheter, the single-lumen catheter folded at a fold proximal of the closed end of the catheter. ### Claim 3 (depends on 1) The catheter according to claim 1, further comprising a septum disposed between the luminal ingress and the luminal egress, wherein a distal end of the septum is proximal of the closed distal end of the catheter. ### Claim 4 (depends on 1) The catheter according to claim 1, wherein the semipermeable membrane has a pore size configured to allow the blood-borne water in the vessel of the patient to permeate through the semipermeable membrane but not larger blood-borne metabolites including polypeptides or proteins, cell fragments, or cells. ### Claim 5 (depends on 1) The catheter according to claim 1, wherein the abluminal surface of the catheter includes a surface area-increasing means to increase a surface area of the abluminal surface over that without the surface area-increasing means, thereby increasing a flux of the blood-borne water from the vessel of the patient through the semipermeable membrane. ### Claim 6 (depends on 1) The catheter according to claim 1, wherein the influent is an aqueous solution including a dissolved polymer, and wherein the first osmotic concentration is sufficient to create an osmotic potential for removing blood-borne the water from the vessel in excess of that the patient needs through the semipermeable membrane. ### Claim 7 A system for treating hypervolemia, comprising: a) a catheter including: a distal end portion having a closed distal end configured to at least temporarily reside within a vessel of a patient; a luminal ingress joined to a luminal egress at the distal end portion, the luminal ingress designed to convey an influent having a first osmotic concentration to the distal end portion, wherein an abluminal surface of the luminal ingress is configured to be in direct contact with a fluid within the vessel of the patient; and a semipermeable membrane configured to pass blood-borne water from the vessel into at least the distal end portion, the blood-borne water absorbed by the influent to produce an effluent having a second osmotic concentration lower than the first osmotic concentration; and b) a fluid-collection system including: a reservoir configured to collect the effluent; and a pump configured to move one or more fluids of the system including the influent and the effluent. ### Claim 8 (depends on 7) The system according to claim 7, the fluid-collection system further comprising an ultrafiltration membrane configured to produce a membrane permeate consisting essentially of the blood-borne water from the vessel of the patient and a membrane retentate for the influent. ### Claim 9 (depends on 8) The system according to claim 8, the fluid-collection system further comprising a shunt configured to shunt the membrane permeate to a bladder of the patient for elimination. ### Claim 10 (depends on 8) The system according to claim 8, the fluid-collection system further comprising a switch valve configured to switch a mode of the fluid-collection system from collecting the blood-borne water from the vessel of the patient in the reservoir to producing the membrane permeate and the membrane retentate for the influent. ### Claim 11 (depends on 7) The system according to claim 7, the catheter further comprising a septum disposed between the luminal ingress and the luminal egress, wherein a distal end of the septum is proximal of the closed distal end of the catheter. ### Claim 12 (depends on 7) The system according to claim 7, wherein the semipermeable membrane has a pore size configured to allow the blood-borne water in the vessel of the patient to permeate through the semipermeable membrane but not larger blood-borne metabolites including polypeptides or proteins, cell fragments, or cells. ### Claim 13 (depends on 7) The system according to claim 7, wherein the influent is an aqueous solution including a dissolved polymer, and wherein the first osmotic concentration is sufficient to create an osmotic potential for removing the blood-borne water from the vessel in excess of that the patient needs through the semipermeable membrane. ### Claim 14 A method for treating hypervolemia, comprising: inserting a closed-ended catheter in a vessel of a patient, the close-ended catheter comprising: a distal end portion; a luminal ingress joined to a luminal egress at the distal end portion; and a semipermeable membrane; directing an influent into the luminal ingress having a first osmotic concentration; absorbing blood-borne water from the vessel into at least the distal end portion through the semipermeable membrane to produce an effluent having a second osmotic concentration lower than the first osmotic concentration; and directing the effluent out of the closed-ended catheter by way of the luminal egress. ### Claim 15 (depends on 14) The method according to claim 14, further comprising: pumping the influent into the luminal ingress and pumping the effluent out of the luminal egress with a pump fluidly coupled to the closed-ended catheter. ### Claim 16 (depends on 14) The method according to claim 14, further comprising: disposing the effluent as a waste product. ### Claim 17 (depends on 14) The method according to claim 14, further comprising: recycling the effluent with a fluid-collection system to produce the influent. ### Claim 18 (depends on 17) The method according to claim 17, wherein directing the effluent out of the closed-ended catheter includes directing the effluent into a fluid reservoir of the fluid-collection system. ### Claim 19 (depends on 18) The method according to claim 18, further comprising: switching a mode of the fluid-collection system from collecting the effluent with the fluid reservoir to filtering the effluent with an ultrafiltration membrane of the fluid-collection system, wherein filtering the effluent produces a water-based membrane permeate and a membrane retentate of the influent. ### Claim 20 (depends on 19) The method according to claim 19, further comprising: shunting the water-based membrane permeate to a bladder of the patient for elimination. ### Claim 21 (depends on 1) The catheter according to claim 1, wherein the semipermeable membrane is disposed at the distal end portion. ### Claim 22 (depends on 7) The system according to claim 7, wherein the semipermeable membrane is disposed at the distal end portion. ### Claim 23 (depends on 14) The method according to claim 14, wherein the semipermeable membrane is disposed at the distal end portion.