Inorganic salt-protein composite medical instrument
AssigneesCell-Medicine, Inc., National Institute of Advanced Industrial Science and Technology, University of Tsukuba, Nihon Parkerizing Co., Ltd.
InventorsTadao Ohno, Mayu Yasunaga, Atsuo Ito, Yu Sogo, Fumiko Kobayashi
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Abstract
A medical instrument in which an inorganic salt solid such as apatite into which a peptide hormone or the like is embedded is placed so that a metal or the like is coated therewith, in which the inorganic salt solid is provided by controlled delay co-precipitation or the like in an unstable supersaturated calcium phosphate solution, and the medical instrument is exposed to ionizing radiation at a dose sufficient for sterilization.
Claims6
A method for producing a medical instrument for use in mammals including human beings, comprising a step of coating a part or entirety of a substance with a crystalline or an amorphous inorganic salt into which a protein having bioactivity and heparin are embedded, and a step of exposing the coated substance to a gamma ray and/or an electron beam at a dose sufficient for sterilization in a condition where generation of radical is suppressed, wherein,
- the substance is a metal, a ceramic, or both,
- the inorganic salt is at least one inorganic salt selected from the group consisting of apatite, tricalcium phosphate, octacalcium phosphate, amorphous calcium phosphate, and calcium carbonate, and
- the condition is a degassing state at an atmospheric pressure of 50 kPa or less.
Dependencies are inferred from the claim text.