Compositions and methods for adhesion to surfaces

An injectable adhesive composition comprising alpha tricalcium phosphate, an organic phosphate compound of Formula (I), and an aqueous medium, wherein:

• (i) the injectable adhesive composition comprises about 5% to about 50% aqueous medium;
• (ii) the viscosity of the injectable adhesive composition is between 100 cP and 10,000 cP when in the fluid state;
• (iii) the alpha tricalcium phosphate is provided as a powder, wherein the mean particle size of the alpha tricalcium powder particles is between 0.001 mm and 0.150 mm;
• and
• (v) the organic phosphate compound of Formula (I) has the structure of:
• or a salt thereof, wherein:
• L is O, S, NH, or CH2;
• each of R1a and R1b is independently H, optionally substituted alkyl, or optionally substituted aryl;
• R2 is H, NR4aR4b, C(O)R5, or C(O)OR5;
• R3 is H, optionally substituted alkyl, or optionally substituted aryl;
• each of R4a and R4b is independently H, C(O)R6, or optionally substituted alkyl;
• R5 is H, optionally substituted alkyl, or optionally substituted aryl;
• R6 is optionally substituted alkyl or optionally substituted aryl;
• and
• each of x and y is independently 0, 1, 2, or 3.