# US 12,178,922 B2 · Patch with DMSO in adhesive layer > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,178,922 B2 - Document ID: US12178922B2 - Status: Granted - Kind: B2 - Application number: 17/244,552 - Filed: 2021-04-29 - Published: 2021-08-19 - Granted: 2024-12-31 - Earliest claimed: 2016-12-28 - Assignees: Hisamitsu Pharmaceutical Co., Inc. - Applicants: Hisamitsu Pharmaceutical Co., Inc. - Inventors: Ryo Tanaka; Hideaki Ohashi; Naruhide Miyoshi; Takito Shima; Naoko Fujita; Yasunari Michinaka - Web page: https://patentgrep.com/patent/US12178922B2 ## CPC - A61K 9/7053: {obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene} - A61K 9/7061: {Polyacrylates} - A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)} - A61K 9/7069: {obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide} - A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)} - A61K 31/196: the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil - A61K 31/405: Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin - A61K 47/12: Carboxylic acids; Salts or anhydrides thereof - A61K 47/20: containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids - A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear. ## Claims ### Claim 1 A patch comprising: a backing layer; an adhesive layer laminated on the backing layer, wherein the backing layer is a monolayer, wherein a water vapor transmission rate of the backing layer is 2077 g/m2·24 hours or more, the adhesive layer comprises a drug, dimethylsulfoxide (DMSO), and an adhesive, wherein the DMSO initial concentration % is 2 to 12 mass %, based on the total mass of the adhesive layer, and wherein the backing layer comprises one or more materials selected from the group consisting of a polyester, a polyurethane, a polyolefin, a polyamide and a cellulose. ### Claim 2 (depends on 1) The patch according to claim 1, wherein the water vapor transmission rate of the backing layer is 4000 g/m2·24 hours or more. ### Claim 3 (depends on 1) The patch according to claim 1, wherein the water vapor transmission rate of the backing layer is 5500 g/m2·24 hours or more. ### Claim 4 (depends on 1) The patch according to claim 1, wherein the adhesive layer comprises at least one adhesive selected from the group consisting of a rubber adhesive, an acrylic adhesive and a silicone adhesive. ### Claim 5 (depends on 1) The patch according to claim 1, wherein the adhesive layer comprises a styrene-isoprene-styrene block copolymer. ### Claim 6 (depends on 1) The patch according to claim 1, wherein the drug is one or more drugs selected from the group consisting of ketoprofen, diclofenac sodium and indomethacin. ### Claim 7 (depends on 6) The patch according to claim 6, wherein the adhesive layer further comprises an organic acid. ### Claim 8 (depends on 5) The patch according to claim 5, wherein the drug is one or more drugs selected from the group consisting of ketoprofen, diclofenac sodium and indomethacin. ### Claim 9 (depends on 8) The patch according to claim 8, wherein the adhesive layer further comprises an organic acid. ### Claim 10 (depends on 1) The patch according to claim 1, wherein the DMSO initial concentration % by mass is 2% by mass to 10% by mass. ### Claim 11 (depends on 10) The patch according to claim 10, wherein the DMSO initial concentration % by mass is 2% by mass to 8% by mass. ### Claim 12 A patch comprising: a backing layer; an adhesive layer laminated on the backing layer, wherein the backing layer is a monolayer, wherein a water vapor transmission rate of the backing layer is 2077 g/m2·24 hours or more, the adhesive layer comprises a drug, dimethylsulfoxide (DMSO), and an adhesive, and wherein a DMSO concentration % by mass after 24 hours of wear, vs. the initial DMSO concentration %, is 3 to 12, and wherein the backing layer comprises one or more materials selected from the group consisting of a polyester, a polyurethane, polyolefin, a polyamide and a cellulose. ### Claim 13 (depends on 1) The patch according to claim 1, wherein the backing layer comprises one or more materials selected from the group consisting of a knit fabric made of polyethylene terephthalate (PET), a nonwoven fabric made of PET fibers, and a polyester fabric. ### Claim 14 (depends on 13) The patch according to claim 13, wherein the backing layer comprises one or more materials selected from the group consisting of a knit fabric made of polyethylene terephthalate (PET), a nonwoven fabric made of PET fibers, and a polyester fabric.