Methods and systems for producing, using, and administering hyperpolarized fluids
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsClifford Russell Bowers, Wenbo Zhao
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Abstract
Methods of and systems for making a hyperpolarized fluid are provided, which include exposing a fluid and parahydrogen to a catalyst. The hyperpolarized fluid can be introduced to a subject. The hyperpolarized fluid can be included in methods of imaging a subject. Also provided are methods that use the hyperpolarized fluids for detecting protein ligand interactions and for enhancing the NMR signals of biopolymers having chemically exchangeable protons.
Claims8
A method of making a hyperpolarized fluid, comprising:
- exposing a fluid and parahydrogen to a catalyst, where the fluid is a liquid or a gas and where the catalyst is an intermetallic nanoparticle heterogeneous catalyst and comprises cube, octahedron, or rod-shaped CeO2 nanocrystals, wherein the fluid is selected from the group consisting of:
- water, methanol, ethanol, propanol, methylamine, ammonia, ethaneamide, methanamide, and a combination thereof;
- making hyperpolarized fluid upon an interaction of the fluid, the parahydrogen, and the catalyst, wherein the catalyst has surface properties that restrict diffusion of hydrogen ad-atoms, and wherein the interaction does not result in hydrogenation of the fluid;
- introducing the hyperpolarized fluid to a subject for the purpose of renal or coronary angiography, wherein the hyperpolarized fluid is a contrast agent;
- and
- acquiring an image of subject using an imaging device.
A method of making a hyperpolarized fluid, comprising:
- exposing a fluid and parahydrogen to a catalyst, where the fluid is a liquid or a gas and where the catalyst is an intermetallic nanoparticle heterogeneous catalyst and comprises cube, octahedron, or rod-shaped CeO2 nanocrystals, wherein the fluid comprises water diluted in an aprotic solvent, wherein the aprotic solvent is selected from the group consisting of dioxane, nitromethane, acetonitrile, acetone, dichloromethane, and a combination thereof, in their per-deuterated or partially deuterated forms;
- making hyperpolarized fluid upon an interaction of the fluid, the parahydrogen, and the catalyst, wherein the catalyst has surface properties that restrict diffusion of hydrogen ad-atoms, and wherein the interaction does not result in hydrogenation of the fluid;
- introducing the hyperpolarized fluid to a subject for the purpose of renal or coronary angiography, wherein the hyperpolarized fluid is a contrast agent;
- and
- acquiring an image of subject using an imaging device.
A method of making a hyperpolarized fluid, comprising:
- exposing a fluid and parahydrogen to a catalyst, where the fluid is a liquid or a gas and where the catalyst is an intermetallic nanoparticle heterogeneous catalyst and comprises cube, octahedron, or rod-shaped CeO2 nanocrystals, wherein the fluid is selected from the group consisting of:
- water, methanol, ethanol, propanol, methylamine, ammonia, ethaneamide, methanamide, and a combination thereof;
- making hyperpolarized fluid upon an interaction of the fluid, the parahydrogen, and the catalyst, wherein the catalyst has surface properties that restrict diffusion of hydrogen ad-atoms, and wherein the interaction does not result in hydrogenation of the fluid;
- and
- condensing the hyperpolarized fluid as a hyperpolarized solid.
Dependencies are inferred from the claim text.