Amyloid peptide scaffolds coordinate with Alzheimer's disease drugs
AssigneesUniversity of Massachusetts, The Texas A&M University System
InventorsManos Gkikas, Phanourios Tamamis, Sai Jonnalagadda
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Abstract
A complex includes an amyloid peptide complexed with a cholinesterase inhibitor, an NMDA receptor antagonist, or a combination, of a cholinesterase inhibitor and an NMDA receptor antagonist, wherein the amyloid peptide comprises X1X2GAIIGX3X4 (SEQ ID NO: 2), wherein X1 and X4 are each independently YF or FY, and X2 and X3 are each 1 amino acid long, and are each independently T, N, S, or Q; or X2 and X3 are each 2 amino acid long and X2 is (Y or F)T, (Y or F)N, (Y or F)S or (Y or F)Q, and X3 is T(Y or F), N(Y or F), S(Y or F) or Q(Y or F), wherein the amyloid peptide self-assembles into amyloid fibrils, and wherein the peptide has a total length of 11-13 amino acids.
Claims9
A complex comprising an amyloid complexed with a cholinesterase inhibitor, an NMDA receptor antagonist, or a combination of a cholinesterase inhibitor and an NMDA receptor antagonist,
- wherein the amyloid peptide comprises
- X1X2GAIIGX3X4 (SEQ ID NO:
- 2), wherein
- X1 and X4 are each independently YF or FY, and
- X2 and X3 are each 1 amino acid long, and are each independently T, N, S, or Q;
- or X2 and X3 are each 2 amino acid long and X2 is (Y or F)T, (Y or F)N, (Y or F)S or (Y or F)Q, and X3 is T(Y or F), N(Y or F), S(Y or F) or Q(Y or F),
- wherein the amyloid peptide self-assembles into fibrils, and wherein the peptide has a total length of 11-13 amino acids.
Dependencies are inferred from the claim text.