Insulin formulations and uses in infusion devices
AssigneeWillow Laboratories, Inc.
InventorsMassi Joe E. Kiani, Kevin Hughes Pauley, Venkatramanan Krishnamani
Life of this patent
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Abstract
Embodiments of the present disclosure provide insulin formulations having a near neutral pH and improved pharmacokinetic/pharmacodynamic properties, and uses in insulin infusion devices that may provide extended infusion period up to 7-14 days. Also provided are systems for administering insulin, the system may include a first reservoir, a second reservoir, an insulin pump configured to administer contents of the first reservoir or the second reservoir, and one or more hardware processors in communication with the insulin pump.
Claims13
A system for administering insulin, the system comprising:
- a sensor configured to detect blood glucose concentration of a subject;
- a device for administering insulin, the device comprising
- a first reservoir comprising an effective amount of insulin, wherein the insulin has a pH between about 6.8 and about 7.4;
- and
- a second reservoir comprising one or more insulin adjunctive excipients, wherein the insulin adjunctive excipients comprise at least one hyaluronidase;
- an insulin pump configured to administer contents from the device to the subject;
- one or more hardware processors in communication with the insulin pump, the one or more hardware processors configured to:
- receive a signal from the sensor indicative of a blood glucose concentration;
- determine, based at least in part on the blood glucose concentration, a desired insulin response speed;
- determine, based on the desired insulin response speed, a first infusion amount of insulin and a second infusion amount of insulin adjunctive excipients;
- and
- administer, using the insulin pump, the first infusion amount of insulin and the second infusion amount of insulin adjunctive excipients, wherein the volumetric ratio of the first infusion amount and second infusion amount is tunable to achieve a particular pharmacokinetic/pharmacodynamic response from the subject.
Dependencies are inferred from the claim text.