# US 12,178,828 B1 · Method for making nano-sized chitosan/VS2 nanocomposites

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- Number: US 12,178,828 B1
- Document ID: US12178828B1
- Status: Granted
- Kind: B1
- Application number: 18/439,336
- Filed: 2024-02-12
- Granted: 2024-12-31
- Earliest claimed: 2023-11-13
- Assignees: King Faisal University
- Applicants: King Faisal University
- Inventors: Mai Mostafa Khalaf Ali; Hany Mohamed Abd El-Lateef Ahmed; Enas T. Aljohani; Hessah A. Al-Abdulkarim; Ahmed M. Abu-Dief
- Web page: https://patentgrep.com/patent/US12178828B1

## CPC

- A61K 31/722: Chitin, chitosan
- A61K 47/02: Inorganic compounds
- A61K 47/61: the organic macromolecular compound being a polysaccharide or a derivative thereof
- A61P 31/04: Antibacterial agents
- A61P 35/00: Antineoplastic agents
- A61K 2121/00: Preparations for use in therapy
- B82Y 5/00: Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- B82Y: SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES

## Abstract

A nano-sized chitosan/VS2 nanocomposite for use in various pharmaceutical applications. The nano-sized chitosan/VS2 nanocomposite can be formed as a flower nanocomposite.

## Claims

### Claim 1

A method for making a chitosan/VS2 nano composite, the method comprising:
stirring chitosan in an acetic acid solution to produce a chitosan solution;
adjusting pH of the chitosan solution to a pH of about 6 to about 7 to obtain a pH adjusted chitosan solution;
adding a VS2 nanoflower to the pH adjusted chitosan solution while stirring to obtain a mixture;
drying the mixture to remove any remaining acetic acid; and
obtaining the chitosan/VS2 nano composite;
wherein the chitosan/VS2 nano composite is formed as flower-like particles, and
the VS2 is immobilized on the chitosan.

### Claim 2 (depends on 1)

The method for making the chitosan/VS2 nano composite of claim 1, wherein the chitosan is stirred in the acetic acid solution for about 5 hours.

### Claim 3 (depends on 1)

The method for making the chitosan/VS2 nano composite of claim 1, wherein the chitosan solution has a concentration of chitosan of about 2% w/v.

### Claim 4 (depends on 1)

The method for making the chitosan/VS2 nano composite of claim 1, wherein the pH of the chitosan solution is adjusted by adding a 0.5 M NaOH solution.

### Claim 5 (depends on 1)

The method for making the chitosan/VS2 nano composite of claim 1, wherein the mixture is dried for about 4 hours at about 60° C.

### Claim 6 (depends on 1)

The method for making the chitosan/VS2 nano composite of claim 1, wherein the dried mixture is dehydrated.