# US 12,178,800 B2 · Sulforaphane-melatonin-like compound

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- Number: US 12,178,800 B2
- Document ID: US12178800B2
- Status: Granted
- Kind: B2
- Application number: 17/271,727
- Filed: 2019-08-27
- Published: 2021-10-14
- Granted: 2024-12-31
- Earliest claimed: 2018-08-28
- Assignees: Perpetuum Ventures NV
- Applicants: Perpetuum Ventures NV
- Inventors: James Troch; Jeroen Hofenk
- Web page: https://patentgrep.com/patent/US12178800B2

## CPC

- A61K 31/4045: Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A61P 39/06: Free radical scavengers or antioxidants
- A61K 31/26: Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 47/55: the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 17/16: Emollients or protectives, e.g. against radiation
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A composition comprising a compound that comprises or consists of a conjugation of 6-hydroxymelatonin and 6-methylsufinylhexyl isothiocyanate is disclosed, as well as this composition for the use as a medicament. Furthermore, this composition for the use in a method of treating and/or preventing an epithelial tissue disease and/or disorder is disclosed.

## Claims

### Claim 1

A composition comprising a compound that comprises or consists of a conjugation of 6-hydroxymelatonin (6OHM) and 6-methylsulfinylhexyl isothiocyanate (6-HITC), the conjugation (6OHM-6-HITC) having the structural formula:

### Claim 2 (depends on 1)

The composition according to claim 1, wherein said composition further comprises 200 mg of carbopol added to 2.5 mL of distilled water and solubilizing 200 mg of 6OHM-6-HITC in 2 mL of ethanol.

### Claim 3 (depends on 1)

The composition according to claim 1, wherein said composition further comprises dissolving 6OHM-6-HITC compound in 1 M NaOH solution, adjusting the pH to 7 with 1 M HCL, and adjusting the concentration to 3 mg/mL or 15 mg/mL in 0.9% (physiologic) saline solution.

### Claim 4 (depends on 3)

The composition according to claim 3, wherein said composition further comprises a solubilizer, a skin permeation enhancer, a preservative, a moisturizer, a gelling agent, a buffering agent, a surfactant, an emulsifier, an emollient, a thickening agent, a stabilizer, a humectant, a dispersing agent and/or any combination thereof.

### Claim 5 (depends on 3)

The composition according to claim 3, wherein said composition comprises a carrier, a diluent and/or an excipient to facilitate uptake of the composition in or on the body.

### Claim 6 (depends on 3)

The composition according to claim 3, wherein said composition further comprises an antibiotic, an antibacterial and/or an antifungal agent.

### Claim 7 (depends on 2)

The composition according to claim 2, wherein said composition further comprises a solubilizer, a skin permeation enhancer, a preservative, a moisturizer, a gelling agent, a buffering agent, a surfactant, an emulsifier, an emollient, a thickening agent, a stabilizer, a humectant, a dispersing agent and/or any combination thereof.

### Claim 8 (depends on 2)

The composition according to claim 2, wherein said composition comprises a carrier, a diluent and/or an excipient to facilitate uptake of the composition in or on the body.

### Claim 9 (depends on 8)

The composition according to claim 8, wherein said carrier and/or said excipient comprises an encapsulating material for at least temporarily encapsulating said compound.

### Claim 10 (depends on 8)

The composition according to claim 8, wherein said carrier and/or said excipient comprises a liposome.

### Claim 11 (depends on 2)

The composition according to claim 2, wherein said composition further comprises an antibiotic, an antibacterial and/or an antifungal agent.