# US 12,178,782 B2 · Drug powderization within vials > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,178,782 B2 - Document ID: US12178782B2 - Status: Granted - Kind: B2 - Application number: 17/211,523 - Filed: 2021-03-24 - Published: 2022-09-29 - Granted: 2024-12-31 - Earliest claimed: 2021-03-24 - Assignees: CMPD Licensing, LLC - Applicants: CMPD Licensing, LLC - Inventors: Jay Richard Ray, II; Jasper Joseph Lovoi, III - Web page: https://patentgrep.com/patent/US12178782B2 ## CPC - A61J 1/2096: {Combination of a vial and a syringe for transferring or mixing their contents} - A61J 1/201: {having one piercing end} - A61J 1/2037: {having valve means} - A61J 1/2051: {having tap means, e.g. tap means activated by sliding} - A61J 1/2089: {Containers or vials which are to be joined to each other in order to mix their contents (combinations of vial and syringe for mixing their contents A61J1/2096)} - A61J 3/02: into the form of powders (pulverising in general B02C) - A61J 1/065: {Rigid ampoules, e.g. glass ampoules} - A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE ## Abstract A method of powderizing a dry cake pharmaceutical drug product for injection within a vial may include securing a vial containing a dry cake pharmaceutical drug product for injection to a shaker device and powderizing the dry cake pharmaceutical drug product within the vial by shaking the vial with the shaker device operated at between about 100 to about 5000 cycles per minute for between about 10 minutes and about 1 hour. ## Claims ### Claim 1 A method of powderizing a dry cake pharmaceutical drug product for injection within a vial, the method comprising: securing a vial containing a dry cake pharmaceutical drug product for injection to a shaker device; and powderizing the dry cake pharmaceutical drug product for injection within the vial by shaking the vial with the shaker device operated at between about 100 to about 5000 cycles per minute for between about 10 minutes and about 1 hour. ### Claim 2 (depends on 1) The method of claim 1, further comprising maintaining a sterile seal under a cap of the vial during the powderization. ### Claim 3 (depends on 1) The method of claim 1, wherein the shaker device comprises a vortex mixer and the cycles per minute are revolutions per minute. ### Claim 4 (depends on 3) The method of claim 3, wherein securing the vial to the shaker device comprises positioning the vial within a retainer housing. ### Claim 5 (depends on 4) The method of claim 4, wherein the retainer housing comprises a container, and wherein positioning the vial within the retainer housing comprises positioning the vial within an interior volume of the container. ### Claim 6 (depends on 5) The method of claim 5, further comprising maintaining a sterile seal under a cap of the vial during the powderization. ### Claim 7 (depends on 5) The method of claim 5, wherein the container is removably attachable to an arm of the shaker device that outputs the shaking motion of the shaker device. ### Claim 8 (depends on 5) The method of claim 5, wherein the container includes a cap and the method includes securing the cap to the container before shaking the vial with the shaker device. ### Claim 9 (depends on 5) The method of claim 5, wherein the shaker device is operated at between about 2500 and about 5000 cycles per minute for between about 10 minutes and about 20 minutes. ### Claim 10 (depends on 1) The method of claim 1, wherein securing the vial to the shaker device comprises positioning the vial within a retainer housing, and wherein the retainer housing comprises a bracket configured to receive and secure the vial to the shaker device. ### Claim 11 (depends on 1) The method of claim 1, wherein the dry pharmaceutical drug product for injection is selected from amphotericin B, voriconazole, colistimethate, vancomycin, streptomycin, acyclovir, remdesivir, or ganciclovir. ### Claim 12 A method of powderizing a dry cake pharmaceutical drug product for injection within a vial, the method comprising: securing a vial containing a dry cake pharmaceutical drug product for injection to a vortex mixer; and powderizing the dry cake pharmaceutical drug product for injection within the vial by shaking the vial with the shaker device operated at between about 2500 to about 5000 revolutions per minute for between about 10 minutes and about 1 hour. ### Claim 13 (depends on 12) The method of claim 12, further comprising maintaining a sterile seal under a cap of the vial during the powderization. ### Claim 14 (depends on 13) The method of claim 13, wherein securing the vial to the shaker device comprises positioning the vial within a retainer housing, wherein the retainer housing comprises a container, wherein positioning the vial within the retainer housing comprises positioning the vial within an interior volume of the container, wherein the container is removably attachable to an arm of the shaker device that outputs the shaking motion of the shaker device, and wherein the container includes a cap and the method includes securing the cap to the container before shaking the vial with the shaker device. ### Claim 15 (depends on 14) The method of claim 14, wherein the dry pharmaceutical drug product for injection is selected from amphotericin B, voriconazole, colistimethate, vancomycin, streptomycin, acyclovir, remdesivir, or ganciclovir. ### Claim 16 A method of powderizing a dry cake pharmaceutical drug product for injection within a vial, the method comprising: securing a vial containing a dry cake pharmaceutical drug product for injection to a shaker device; powderizing the dry cake pharmaceutical drug product for injection within the vial by shaking the vial with the shaker device operated at between about 2500 to about 5000 revolutions per minute for between about 10 minutes and about 1 hour; and maintaining a sterile seal under a cap of the vial during the powderization, wherein securing the vial to the shaker device comprises positioning the vial within a retainer housing, wherein the retainer housing comprises a container, wherein positioning the vial within the retainer housing comprises positioning the vial within an interior volume of the container, wherein the container is removably attachable to an arm of the shaker device that outputs the shaking motion of the shaker device, and wherein the container includes a cap and the method includes securing the cap to the container before shaking the vial with the shaker device. ### Claim 17 (depends on 16) The method of claim 16, wherein the dry pharmaceutical drug product for injection is selected from amphotericin B, voriconazole, colistimethate, vancomycin, streptomycin, acyclovir, remdesivir, or ganciclovir.