# US 12,178,781 B2 · Combinatorial drug delivery device

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- Number: US 12,178,781 B2
- Document ID: US12178781B2
- Status: Granted
- Kind: B2
- Application number: 18/473,233
- Filed: 2023-09-23
- Published: 2024-01-11
- Granted: 2024-12-31
- Earliest claimed: 2018-05-11
- Assignees: Bristol-Myers Squibb Company
- Applicants: Bristol-Myers Squibb Company
- Inventors: Martin John McLoughlin; Chester Larrow; Mariano Mumpower
- Web page: https://patentgrep.com/patent/US12178781B2

## CPC

- A61J 1/20: Arrangements for transferring {or mixing} fluids, e.g. from vial to syringe
- A61J 1/1475: {Inlet or outlet ports}
- A61J 1/16: Holders for containers
- A61J 1/2006: {Piercing means}
- A61J 1/201: {having one piercing end}
- A61J 1/2058: {having multiple connecting ports}
- A61J 1/2068: {Venting means}
- A61J 1/2075: {for external venting}
- A61J 1/2089: {Containers or vials which are to be joined to each other in order to mix their contents (combinations of vial and syringe for mixing their contents A61J1/2096)}
- A61J 3/002: {Compounding apparatus specially for enteral or parenteral nutritive solutions (bottling liquids B67C)}
- A61M 5/1407: {Infusion of two or more substances}
- A61M 5/1408: {in parallel, e.g. by manifolds or with sequencing valves}
- A61M 5/1409: {in series, e.g. reconstitution systems with a first substance passing through a container holding a second substance}
- A61M 5/1413: {Modular systems comprising interconnecting elements}
- A61M 5/14248: {of the skin patch type}
- A61M 2005/14268: {with a reusable and a disposable component}
- A61M 2209/045: for filling, e.g. for filling reservoirs
- A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components. The device includes a plurality of modules, each including: a body having an interior volume; a spike plate movably disposed in the interior volume, the spike plate having a protruding cannula and first and second ports. The device also includes a base tray which includes: a framework defining a plurality of wells, each of the wells formed to insertingly receive one of the modules; for each of the wells, first and second inlet ports formed to interface with the first and second ports of the module being received in the respective well; passageways to connect certain wells with adjacent wells to permit fluid flow therebetween. For each of the wells, the spike plate of the respective module being maintained in a stationary position with the module being inserted into the well.

## Claims

### Claim 1

A combinatorial drug delivery device for delivering a predetermined selection of drug components, each of the drug components being contained in a drug vial, the device comprising:
a plurality of modules, wherein each of the modules includes:
a body having an interior volume formed to accommodate a drug vial in a first portion of the interior volume;
a spike plate having a plate-shaped body with opposing first and second faces, a cannula protruding from the first face, first and second ports protruding from the second face, wherein the plate-shaped body is located wholly within, and movable relative to, the interior volume, wherein, the cannula terminates at a free end, first and second openings being formed in the free end with first and second lumens extending therefrom, through the cannula and terminating at the first and second ports, respectively, and, wherein, the plate-shaped body is releasably retained in an initial state within the interior volume, spaced from the first portion; and,
a base tray including:
a framework defining a plurality of wells, each of the wells formed to insertingly receive one of the modules;
for each of the wells, first and second inlet ports formed to interface with the first and second ports of the module being received in the respective well in forming sealed flow paths therebetween;
passageways to connect the second inlet ports of certain wells with the first inlet ports of wells adjacent to the certain wells to permit fluid flow therebetween,
wherein, for each of the wells, with the module being sufficiently inserted into the respective well, the plate-shaped body is released from the initial state to allow the body to move relative to the plate-shaped body and cause the first portion of the interior volume to move towards the cannula.

### Claim 2 (depends on 1)

The drug delivery device as in claim 1, further comprising a source of negative pressure to draw the drug components from the modules.

### Claim 3 (depends on 2)

The drug delivery device as in claim 2, wherein the base tray includes a housing, the source of negative pressure being located in the housing.

### Claim 4 (depends on 1)

The drug delivery device as in claim 1, wherein the body includes a lid.

### Claim 5 (depends on 4)

The drug delivery device as in claim 4, wherein the plate-shaped body is located wholly within the lid.

### Claim 6 (depends on 4)

The drug delivery device as in claim 4, wherein the lid includes access openings.

### Claim 7 (depends on 6)

The drug delivery device as in claim 6, wherein the plate-shaped body is movable from the initial state in a direction away from the access openings.

### Claim 8 (depends on 1)

The drug delivery device as in claim 1, wherein the plate-shaped body includes a deflectable detent to releasably retain the plate-shaped body in the initial state.

### Claim 9 (depends on 8)

The drug delivery device as in claim 8, wherein the body includes a ridge or channel to cooperatively engage the deflectable detent in releasably retaining the plate-shaped body.